An investigation of the action of disease modifying antirheumatic drugs on the rheumatoid synovial membrane: reduction in T lymphocyte subpopulations and HLA-DP and DQ antigen expression after gold or penicillamine therapy.
An investigation of the action of disease modifying antirheumatic drugs on the rheumatoid synovial membrane: reduction in T lymphocyte subpopulations and HLA-DP and DQ antigen expression after gold or penicillamine therapy.
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疾病缓解抗风湿药物对类风湿滑膜作用的研究：金或青霉胺治疗后 T 淋巴细胞亚群以及 HLA-DP 和 DQ 抗原表达的减少。
DOI：
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发表时间：
1987
影响因子：
27.4
通讯作者：
M. Cawley
中科院分区：
文献类型：
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作者：
M. T. Walters;J. Smith;K. Moore;P. R. Evans;M. Cawley
在金或青霉胺（疾病缓解药物，DMD）治疗六个月之前和之后，对七名类风湿性关节炎（RA）患者的膝关节滑液针活检标本进行了免疫组织化学检查。与抑制/细胞毒性亚群相比，浸润性 T 淋巴细胞数量显着减少，辅助/诱导亚群淋巴细胞数量下降不成比例。这导致辅助细胞/诱导细胞与抑制细胞/细胞毒性细胞的比率下降。免疫组织学变化与红细胞沉降率（ESR）、血清免疫球蛋白、视觉模拟疼痛评估、握力和里奇关节指数的改善相关。第二组 9 名 RA 患者已经接受 DMD 治疗，但在 6 个月后没有表现出类似的变化。 HLA II 类抗原 DR、DQ 和 DP 在一组从未接受过疾病调节药物治疗的 RA 患者的淋巴细胞、巨噬细胞和滑膜衬里细胞上广泛表达。治疗后，HLA-DP 和 DQ 抗原的表达显着降低。
Synovial needle biopsy specimens from the knee joints of seven patients with rheumatoid arthritis (RA) were examined immunohistochemically before and after six months' treatment with either gold or penicillamine (disease modifying drugs, DMDs). There were significant reductions in the numbers of infiltrating T lymphocytes and a disproportionate fall in the numbers of lymphocytes of the helper/inducer subset when compared with those of the suppressor/cytotoxic subset. This resulted in a fall in the ratio of helper/inducer to suppressor/cytotoxic cells. The immunohistological changes correlated with improvements in erythrocyte sedimentation rate (ESR), serum immunoglobulins, visual analogue pain assessment, grip strength, and Ritchie articular index. A second group of nine patients with RA, already well established on DMD therapy, did not show similar changes after the six month period. The HLA class II antigens DR, DQ, and DP were widely expressed on lymphocytes, macrophages, and synovial lining cells of a group of patients with RA who had never received disease modifying drug therapy. After treatment there was a significant reduction in the expression of HLA-DP and DQ antigens.
人类辅助亚系和抑制亚系中 T 淋巴细胞免疫调节亚群的解剖。
DOI：
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发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gatenby,PA;Kansas,GS;Xian,CY;Evans,RL;Engleman,EG
通讯作者：
Engleman,EG