Disrupted dynamic functional network connectivity in fetal alcohol spectrum disorders.
Disrupted dynamic functional network connectivity in fetal alcohol spectrum disorders.
复制标题
胎儿酒精谱系障碍的动态功能网络连接中断。
DOI：
10.1111/acer.15046
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Stephen,JuliaM
中科院分区：
文献类型：
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作者：
Candelaria-Cook,FelichaT;Schendel,MeganE;Flynn,Lucinda;Cerros,Cassandra;Hill,DinaE;Stephen,JuliaM
产前酒精暴露（PAE）可导致有害和持久的神经发育变化。与典型发育对照组（TDC）相比，患有PAE或胎儿酒精谱系障碍（FASD）的儿童的白色体积和静息态光谱功率减少，静息态静态功能连接受损。PAE对静息态动态功能网络连接（dFNC）的影响是未知的。方法使用闭眼和睁眼脑磁图（MEG）静息态数据，对89名6-16岁儿童（51名TDC，38名FASD）的全局dFNC统计和Meta状态进行了检查。源分析的MEG数据被用作组空间独立成分分析的输入，以导出计算dFNC的功能网络。结果在闭眼期间，相对于TDC，FASD参与者在状态2中花费了显著更长的时间，其代表为与TDC的关系（即，默认模式网络（DMN）和视觉网络（VN）内和之间的连接性降低），以及状态4，其以更强的网络间相关性为代表。FASD组表现出更大的动态流动性和动态范围（即，进入更多的状态，更频繁地从一个Meta状态转换到另一个元状态，并且旅行的距离比TDC更远。在睁眼期间，TDC在状态1中花费的时间明显更多，典型的是正面的域内和域间连接，在额叶网络（FN）中具有适度的相关性，而FASD的参与者在状态2中花费的时间更长，典型的是DMN和VN内部和之间的关系，以及FN，注意力网络，结论FASD和TDC儿童之间存在重要的静息态dFNC差异。FASD的参与者表现出更大的动态流动性和动态范围，并花更多的时间在DMN和VN之间的关系，并在一个国家的高互联网络连接为代表的状态。总之，这些网络畸变表明产前酒精暴露对静息状态连接具有全局影响。
BackgroundPrenatal alcohol exposure (PAE) can result in harmful and long‐lasting neurodevelopmental changes. Children with PAE or a fetal alcohol spectrum disorder (FASD) have decreased white matter volume and resting‐state spectral power compared to typically developing controls (TDC) and impaired resting‐state static functional connectivity. The impact of PAE on resting‐state dynamic functional network connectivity (dFNC) is unknown.MethodsUsing eyes‐closed and eyes‐open magnetoencephalography (MEG) resting‐state data, global dFNC statistics and meta‐states were examined in 89 children aged 6–16 years (51 TDC, 38 with FASD). Source analyzed MEG data were used as input to group spatial independent component analysis to derive functional networks from which the dFNC was calculated.ResultsDuring eyes‐closed, relative to TDC, participants with FASD spent a significantly longer time in state 2, typified by anticorrelation (i.e., decreased connectivity) within and between default mode network (DMN) and visual network (VN), and state 4, typified by stronger internetwork correlation. The FASD group exhibited greater dynamic fluidity and dynamic range (i.e., entered more states, changed from one meta‐state to another more often, and traveled greater distances) than TDC. During eyes‐open, TDC spent significantly more time in state 1, typified by positive intra‐ and interdomain connectivity with modest correlation within the frontal network (FN), while participants with FASD spent a larger fraction of time in state 2, typified by anticorrelation within and between DMN and VN and strong correlation within and between FN, attention network, and sensorimotor network.ConclusionsThere are important resting‐state dFNC differences between children with FASD and TDC. Participants with FASD exhibited greater dynamic fluidity and dynamic range and spent more time in states typified by anticorrelation within and between DMN and VN, and more time in a state typified by high internetwork connectivity. Taken together, these network aberrations indicate that prenatal alcohol exposure has a global effect on resting‐state connectivity.