A novel role for syndecan-3 in angiogenesis.
A novel role for syndecan-3 in angiogenesis.
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DOI：
10.12688/f1000research.2-270.v1
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Whiteford JR
中科院分区：
文献类型：
--
作者：
De Rossi G;Whiteford JR
Syndecan-3是硫酸乙酰肝素蛋白聚糖的syndecan家族的四个成员之一，并且已经显示通过其硫酸乙酰肝素链与许多生长因子相互作用。多配体蛋白聚糖-1、-2和-4的细胞外核心蛋白都具有粘附调节基序，我们假设多配体蛋白聚糖-3也可能具有这样的特征。在这里，我们表明，细菌表达的GST融合蛋白组成的整个成熟syndecan-3胞外域具有抗血管生成的特性，并通过调节内皮细胞迁移的行为。这项工作确定syndecan-3作为抗血管生成治疗的可能的治疗靶点。
Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains. The extracellular core proteins of syndecan-1,-2 and -4 all possess adhesion regulatory motifs and we hypothesized that syndecan-3 may also possess such characteristics. Here we show that a bacterially expressed GST fusion protein consisting of the entire mature syndecan-3 ectodomain has anti-angiogenic properties and acts via modulating endothelial cell migration. This work identifies syndecan-3 as a possible therapeutic target for anti-angiogenic therapy.