Clostridioides difficile infection in coronavirus disease 2019 (COVID-19): an underestimated problem?
Clostridioides difficile infection in coronavirus disease 2019 (COVID-19): an underestimated problem?
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DOI：
10.20452/pamw.15715
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发表时间：
2021-02-26
影响因子：
4.8
通讯作者：
Rydzewska, Grazyna
中科院分区：
文献类型：
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作者：
Lewandowski, Konrad;Rosolowski, Mariusz;Rydzewska, Grazyna
介绍在2019年冠状病毒病(新冠肺炎)大流行期间，抗生素的使用和微生物区系破坏的可能性引发了人们对艰难梭状芽胞杆菌感染(CDI)发病率的质疑。目的探讨新冠肺炎患者血管内皮细胞损伤的发生频率及其危险因素。患者和METODs我们对新冠肺炎患者和血透前期患者发生CDI的频率和危险因素进行了一项回顾性的单中心评估研究。分析包括441名感染严重急性呼吸综合征冠状病毒(SARS-CoV-2)的患者和2961名在大流行前住院的患者。结果与流行前相比，新冠肺炎流行期间CDI的发生率显著增加：10.9%比2.6%，P
INTRODuCTION The use of antibiotics and possibility of microbiota disruption during the coronavirus disease 2019 (COVID-19) pandemic have raised questions about the incidence of Clostridioides difficile infection (CDI). OBjECTIvEs This study aimed to assess the frequency of and risk factors for CDI in patients with COVID-19. PATIENTs AND METNODs We conducted a retrospective, single-center evaluation study on the frequency of and risk factors for CDI in patients with COVID-19 and in the prepandemic era. The analysis included 441 patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and 2961 patients hospitalized before the pandemic. REsuLTs A significant increase in the incidence of CDI was noted during the COVID-19 pandemic compared with the prepandemic period: 10.9% versus 2.6%, P