Cutaneous involvement in Hodgkin's disease
Cutaneous involvement in Hodgkin's disease
复制标题
霍奇金病的皮肤受累
作者：
R. White;J. Patterson
在1951年至1980年收治的465例霍奇金氏病患者中，有16例(3.4%)经组织学证实为霍奇金氏病的“特定”皮肤受累。最常见的临床表现是单个或多个真皮或皮下结节。3名患者首次出现皮肤损害。在所有情况下，都可以使用黑麦分类法对皮肤组织学模式进行分类。此外，一名患者的疾病仅限于皮肤和皮下组织的局部区域。此病例很难分类，尽管有一些组织学特征提示淋巴细胞耗竭性霍奇金氏病。结果表明，皮肤受累的三种机制：(1)逆行淋巴扩散，位于受累淋巴结远端(11例)；(2)从潜在结节直接扩散(3例)；(3)血源性扩散(2例)。皮肤受累通常代表或伴随IV期疾病，并带有不祥的预后。讨论了原发性皮肤何杰金氏病诊断中固有的问题。
Among 465 patients with Hodgkin's disease seen from 1951 through 1980, there were 16 (3.4%) who had histologically verified “specific” cutaneous involvement with Hodgkin's disease. The most common clinical presentation was of single or multiple dermal or subcutaneous nodules. Three patients had skin lesions at first presentation. In all instances, it was possible to classify the cutaneous histologic pattern using the Rye Classification. In addition, one patient was seen in whom disease was confined to a localized area of skin and subcutaneous tissue. This case was difficult to classify, although there were some histologic features suggestive of lymphocyte‐depletion Hodgkin's disease. The findings indicate three mechanisms of cutaneous involvement: (1) retrograde lymphatic spread, distal to involved lymph nodes (11 patients); (2) direct extension from an underlying nodal focus (3 patients); and (3) hematogenous dissemination (2 patients). Cutaneous involvement usually represents, or accompanies, Stage IV disease, and carries an ominous prognosis. The problems inherent in the diagnosis of primary cutaneous Hodgkin's disease are discussed.
影响因子：
11.2
作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
通讯作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana