Quantitative plutonium microdistribution in bone tissue of vertebra from a Mayak worker.
Quantitative plutonium microdistribution in bone tissue of vertebra from a Mayak worker.
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玛雅克工人椎骨骨组织中钚的定量微分布。
DOI：
10.1097/hp.0b013e3181cb840f
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发表时间：
2010
期刊：
影响因子：
2.2
通讯作者：
Belosokhov,MaximV
中科院分区：
文献类型：
--
作者：
Lyovkina,YekaterinaV;Miller,ScottC;Romanov,SergeyA;Krahenbuhl,MelindaP;Belosokhov,MaximV
本研究的目的是获得钚在人体骨组织不同结构元素中微分布的定量数据，用于局部剂量评估和剂量学模型验证。胸椎样本是从一名钚负荷相当高的前玛雅克工人那里获得的。获得了关于职业和接触史、病史和器官中测量的钚含量的其他信息。用中子诱发放射自显影技术在聚碳酸酯薄膜的裂变径迹的骨切片中检测到钚。对其中一张放射自显影上随机选择的微视野进行了定量分析。数据包括不同骨组织和表面区域的裂变碎片轨迹。首次获得了钚在人体骨组织中微分布的定量信息。根据这些数据，相应地，骨体积中钚的衰变与骨皮质和骨小梁中骨表面的钚衰变之间的定量关系被定义为2.0和0.4。测量的骨体积衰变与骨表面衰变的定量关系与国际放射防护委员会推荐的皮质骨比例模型不一致。在扩展了钚在人类其他骨骼类型以及不同暴露模式和类型的其他病例中的定量钚微观分布的数据集后，可能需要调整肺外隔室的生物动力学模型参数。
The purpose of this study was to obtain quantitative data on plutonium microdistribution in different structural elements of human bone tissue for local dose assessment and dosimetric models validation. A sample of the thoracic vertebra was obtained from a former Mayak worker with a rather high plutonium burden. Additional information was obtained on occupational and exposure history, medical history, and measured plutonium content in organs. Plutonium was detected in bone sections from its fission tracks in polycarbonate film using neutron-induced autoradiography. Quantitative analysis of randomly selected microscopic fields on one of the autoradiographs was performed. Data included fission fragment tracks in different bone tissue and surface areas. Quantitative information on plutonium microdistribution in human bone tissue was obtained for the first time. From these data, the quantitative relationships of plutonium decays in bone volume to decays on bone surface in cortical and trabecular fractions were defined as 2.0 and 0.4, correspondingly. The measured quantitative relationship of decays in bone volume to decays on bone surface does not coincide with recommended models for the cortical bone fraction by the International Commission on Radiological Protection. Biokinetic model parameters of extrapulmonary compartments might need to be adjusted after expansion of the data set on quantitative plutonium microdistribution in other bone types in humans as well as other cases with different exposure patterns and types of plutonium.