Clinical correlates of the deficit syndrome of schizophrenia.
Clinical correlates of the deficit syndrome of schizophrenia.
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DOI：
10.1176/ajp.147.3.290
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发表时间：
1990-03
期刊：
影响因子：
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通讯作者：
Robert W. Buchanan;Brian Kirkpatrick;D. Heinrichs;William T. Carpenter
中科院分区：
文献类型：
--
作者：
Robert W. Buchanan;Brian Kirkpatrick;D. Heinrichs;William T. Carpenter
作者建议使用原发性和持久性阴性或缺陷症状将精神分裂症患者分为两组，缺陷和非缺陷。这种方法的有效性进行了检查，比较17个赤字和17个nondeficit患者的差异，发病前的调整和神经功能缺损的程度。缺陷患者的特点是较差的病前调整和更大的神经功能缺损。在两组或总患者人群中，神经功能损害与病前调整无关。这些研究结果支持缺陷症状的效用，定义一个更同质的精神分裂症亚组。
The authors propose using primary and enduring negative or deficit symptoms for dichotomizing schizophrenic patients into two groups, deficit and nondeficit. The validity of this approach was examined by comparing 17 deficit and 17 nondeficit patients for differences in premorbid adjustment and degree of neurological impairment. Deficit patients were characterized by poorer premorbid adjustment and greater neurological impairment. Neurological impairment was not related to premorbid adjustment in either group or in the total patient population. These findings support the utility of deficit symptoms for defining a more homogeneous subgroup of schizophrenia.