Three-Dimensional Heterogeneity of Cerebellar Interposed Nucleus-Recipient Zones in the Thalamic Nuclei
Three-Dimensional Heterogeneity of Cerebellar Interposed Nucleus-Recipient Zones in the Thalamic Nuclei
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DOI：
10.1007/s12264-021-00780-y
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发表时间：
2021-10
影响因子：
5.6
通讯作者：
Kuang-Yi Ma;Xin-Yu Cai;Xin-Tai Wang;Zhaoxiang Wang;Wan-Meng Huang;Zhi-Ying Wu;Zhouyan Feng;Ying Shen
中科院分区：
文献类型：
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作者：
Kuang-Yi Ma;Xin-Yu Cai;Xin-Tai Wang;Zhaoxiang Wang;Wan-Meng Huang;Zhi-Ying Wu;Zhouyan Feng;Ying Shen
小脑被概念化为复杂运动的处理器，并且还被赋予认知和情感行为的角色。虽然小脑深核的轴突被称为项目的初级丘脑核，这些预测的特点，如受体区的空间分布，缺乏宏观调查。在这里，我们使用体内电生理记录和跨突触病毒追踪研究了小脑间置核（IpN）向丘脑腹外侧核（VL）和中央外侧核（CL）的输出。我们发现，IpN刺激诱导的单突触诱发电位（EPs）在VL，而不是CL区。此外，由IpN诱导的EP和IpN投射的神经支配在三维空间中的VL区显示出实质性的异质性。这些研究结果表明，IpN输入的受体区之间和丘脑核团内的变化，并可能差异控制丘脑-皮层网络。
The cerebellum is conceptualized as a processor of complex movements and is also endowed with roles in cognitive and emotional behaviors. Although the axons of deep cerebellar nuclei are known to project to primary thalamic nuclei, macroscopic investigation of the characteristics of these projections, such as the spatial distribution of recipient zones, is lacking. Here, we studied the output of the cerebellar interposed nucleus (IpN) to the ventrolateral (VL) and centrolateral (CL) thalamic nuclei using electrophysiological recordingin vivoand trans-synaptic viral tracing. We found that IpN stimulation induced mono-synaptic evoked potentials (EPs) in the VL but not the CL region. Furthermore, both the EPs induced by the IpN and the innervation of IpN projections displayed substantial heterogeneity across the VL region in three-dimensional space. These findings indicate that the recipient zones of IpN inputs vary between and within thalamic nuclei and may differentially control thalamo-cortical networks.