Peptide immunization elicits polyomavirus-specific MHC class ib-restricted CD8 T cells in MHC class ia allogeneic mice.
Peptide immunization elicits polyomavirus-specific MHC class ib-restricted CD8 T cells in MHC class ia allogeneic mice.
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肽免疫在 MHC ia 类同种异体小鼠中引发多瘤病毒特异性 MHC ib 类限制性 CD8 T 细胞。
DOI：
10.1089/vim.2012.0052
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发表时间：
2013
期刊：
影响因子：
2.2
通讯作者：
Lukacher,AronE
中科院分区：
文献类型：
--
作者：
Hofstetter,AmeliaR;Evavold,BrianD;Lukacher,AronE
与多态性 MHC Ia 类分子不同，MHC Ib 类分子是寡态性或非多态性的。我们最近在 H-2b 单倍型小鼠中发现了对小鼠多瘤病毒 (MPyV) 的保护性 CD8 T 细胞反应，该反应受到 H2-Q9（Qa-2 MHC Ib 类家族成员）的限制。在这里，我们证明，用与 Q9 呈递的病毒衣壳衍生肽相对应的肽进行免疫也会在 H-2s 和 H-2g7 品系的小鼠中引发 MHC Ib 类限制性 MPyV 特异性 CD8 T 细胞。这些发现支持这样的概念：用单一 MHC Ib 类限制性肽进行免疫可以在 MHC Ia 类同种异体宿主中扩增 CD8 T 细胞。
Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2bhaplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immunization with a peptide corresponding to a virus capsid-derived peptide presented by Q9 also elicits MHC class Ib-restricted MPyV-specific CD8 T cells in mice of H-2sand H-2g7strains. These findings support the concept that immunization with a single MHC class Ib-restricted peptide can expand CD8 T cells in MHC class Ia allogeneic hosts.