History of psychosis and mania, and outcomes after kidney transplantation - a retrospective study.
History of psychosis and mania, and outcomes after kidney transplantation - a retrospective study.
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DOI：
10.1111/tri.13127
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Kovesdy CP
中科院分区：
文献类型：
--
作者：
Molnar MZ;Eason JD;Gaipov A;Talwar M;Potukuchi PK;Joglekar K;Remport A;Mathe Z;Mucsi I;Novak M;Kalantar-Zadeh K;Kovesdy CP
History of psychosis or mania, if uncontrolled, both represent relative contraindications for kidney transplantation. We examined 3,680 US veterans who underwent kidney transplantation. The diagnosis of history of psychosis/mania was based on a validated algorithm. Measured confounders were used to create a propensity score-matched cohort (n=442). Associations between pre-transplantation psychosis/mania and death with functioning graft, all-cause death, graft loss and rejection were examined in survival models and logistic regression models. Post-transplant medication non-adherence was assessed using proportion of days covered (PDC) for tacrolimus and mycophenolic acid in both groups. The mean±SD age of the cohort at baseline was 61±11 years, 92% were male, 66% and 27% of patients were white and African-American, respectively. Compared to patients without history of psychosis/mania, patients with a history of psychosis/mania had similar risk of death with functioning graft [Sub-Hazard Ratio(SHR)(95%Confidence Interval (CI)): 0.94(0.42–2.09)], all-cause death[Hazard Ratio(95%CI): 1.04(0.51–2.14)], graft loss [SHR(95%CI): 1.07(0.45–2.57)] and rejection [Odds Ratio(95%CI): 1.23(0.60–2.53)]. Moreover, there was no difference in immunosuppresive drug PDC in patients with and without history of psychosis/mania (PDC: 76±21% vs 78±19%, p=0.529 for tacrolimus; PDC: 78±17% vs 79±18%, p=0.666 for mycophenolic acid). After careful selection, pre-transplantation psychosis/mania are not associated with adverse outcomes in kidney transplant recipients.
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影响因子：
37.8
作者：
Kovesdy, Csaba P.;Norris, Keith C.;Kalantar-Zadeh, Kamyar
通讯作者：
Kalantar-Zadeh, Kamyar
影响因子：
23.4
作者：
Kälble, T;Lucan, M;Wiesel, M
通讯作者：
Wiesel, M
DOI：
10.1682/jrrd.2009.08.0112
发表时间：
2010-01-01
影响因子：
--
作者：
Frayne, Susan M.;Berg, Eric;Moos, Rudolf
通讯作者：
Moos, Rudolf
影响因子：
13.2
作者：
Molnar, Miklos Z.;Gosmanova, Elvira O.;Kovesdy, Csaba P.
通讯作者：
Kovesdy, Csaba P.
影响因子：
3.4
作者：
Butler, Mary I.;McCartan, Deirdre;Conlon, Peter
通讯作者：
Conlon, Peter