Immune response to influenza vaccine in healthy elderly:: lack of association with plasma β-carotene, retinol, α-tocopherol, or zinc
Immune response to influenza vaccine in healthy elderly:: lack of association with plasma β-carotene, retinol, α-tocopherol, or zinc
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DOI：
10.1016/s0047-6374(00)00134-2
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发表时间：
2000-08-15
影响因子：
5.3
通讯作者：
Murasko, DM
中科院分区：
文献类型：
--
作者：
Gardner, EM;Bernstein, ED;Murasko, DM
免疫力和营养状况随着年龄的增长而受到影响，但它们之间的关系尚不清楚。对61名健康老年人（平均81岁）和27名健康青年人（平均27岁）接种三价流感疫苗（FLU）前后的免疫应答和血浆微量营养素水平进行了评价。老年人免疫前后Flu诱导的细胞增殖和IFN-γ水平均低于青年人。增殖和IFN-γ水平增加免疫后的年轻人，但不是老年人。FLU-induced IL-6和IL-10的水平没有改变后，免疫组。虽然年轻人和老年人接种疫苗后对所有三种FLU组分的抗体滴度均升高，但老年人接种疫苗后滴度低于年轻人。尽管年轻人和老年人接种疫苗前后的血浆视黄醇和锌水平相似，但老年人在两次评估中的血浆β-胡萝卜素和α-生育酚水平均较高，且在接种疫苗后升高。重要的是，血浆微量营养素水平是相当的老年人或没有完整的（滴度大于或等于40和接种后四倍上升）的抗体反应后接种。这些结果表明，这些血浆微量营养素的差异（1）不需要观察到健康老年人与年轻人相比的FLU反应降低，（2）与健康老年人之间的抗体反应差异无关。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Immunity and nutritional status are compromised with age, yet the relationship between them is unclear. Immune responses and plasma micronutrient levels of 61 healthy elderly (mean 81 years) and 27 young (mean 27 years) were assessed before and after immunization with trivalent influenza vaccine (FLU). FLU-induced proliferation and IFN-gamma levels of elderly were lower than young before and after immunization. Proliferation and IFN-gamma levels increased after immunization of young, but not elderly. FLU-induced IL-6 and IL-10 levels did not change after immunization of either group. While antibody titers to all three FLU components increased after vaccination of young and elderly, post-vaccination titers of elderly were lower than young, Although plasma retinol and zinc levels of young and elderly were similar before and after vaccination, elderly had higher plasma beta-carotene and alpha-tocopherol levels at both assessments that increased after vaccination. Importantly, plasma micronutrient levels were comparable for elderly with or without intact (titers greater than or equal to 40 and fourfold rise post-vaccination) antibody responses after vaccination. These results suggest that differences in these plasma micronutrients (1) are not required to observe decreased FLU responses of healthy elderly compared to young and (2) are not associated with differences in antibody responses among healthy elderly. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.