Molecular embryology for an understanding of congenital heart diseases
Molecular embryology for an understanding of congenital heart diseases
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DOI：
10.1007/s12565-009-0023-4
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发表时间：
2009-09-01
影响因子：
1.2
通讯作者：
Yamagishi, Chihiro
中科院分区：
文献类型：
--
作者：
Yamagishi, Hiroyuki;Maeda, Jun;Yamagishi, Chihiro
先天性心脏病（CHD）是由胚胎心血管系统的异常形态发生所致，通常涉及发育中的心脏和血管的特定结构成分的缺陷。因此，对“分子胚胎学”的理解，特别是关注心血管形态发生所涉及的各个模块步骤，对于那些希望更好地了解先天性心脏病起源的人来说尤为重要。分子胚胎学的最新进展表明，心血管系统源自多个不同的胚胎起源，并且在早期心管前方的咽中胚层中已确定了一群心肌前体细胞，被称为“第二心脏区”。第二心脏区的发现对心脏流出道发育的解释具有重要意义，并为先天性心脏病的形态发生提供了新的见解。
Congenital heart diseases (CHD) result from abnormal morphogenesis of the embryonic cardiovascular system and usually involve defects in specific structural components of the developing heart and vessels. Therefore, an understanding of "Molecular Embryology", with specific focus on the individual modular steps involved in cardiovascular morphogenesis, is particularly relevant to those wishing to have a better insight into the origin of CHD. Recent advances in molecular embryology suggest that the cardiovascular system arises from multiple distinct embryonic origins, and a population of myocardial precursor cells in the pharyngeal mesoderm anterior to the early heart tube, denoted the "second heart field", has been identified. Discovery of the second heart field has important implications for the interpretation of cardiac outflow tract development and provides new insights into the morphogenesis of CHD.