Determinants of the optic cup to disc ratio in an Asian population - The Singapore Malay Eye Study (SiMES)
Determinants of the optic cup to disc ratio in an Asian population - The Singapore Malay Eye Study (SiMES)
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DOI：
10.1001/archopht.126.8.1101
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发表时间：
2008-08-01
影响因子：
--
通讯作者：
Aung, Tin
中科院分区：
文献类型：
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作者：
Amerasinghe, Nishani;Wong, Tien Y.;Aung, Tin
目的：描述的分布和决定因素的视杯盘比（CDR）在马来成年人在新加坡。方法：这项以人口为基础的，年龄分层的研究检查了3280名马来人，年龄在40至80岁，在新加坡。参与者进行了标准化的面试和眼科检查。裂隙灯检查测量的垂直尺寸的光盘和杯，不包括地区的视乳头周围萎缩和Elschnig巩膜ring.Results：垂直CDR记录为3228右眼和3237左眼。双眼的平均（SD）CDR为0.40（0.15）。右眼的CDR随年龄增长而增加（P <0.001），男性比女性更大（年龄调整的CDR，0.42比0.39; P <0.001）。在多元线性回归中，较大CDR的重要决定因素是年龄增加、男性、较高的眼内压（IOP）、较低的舒张压、较低的体重指数和既往白内障手术。其中，较高的IOP是CDR的最重要决定因素。排除149人青光眼，男性性别，高眼压，低舒张压，低体重指数，糖尿病的显着预测更大的CDR。结论：更大的垂直CDR与男性性别，高眼压，低舒张压，低体重指数。
Objective: To describe the distribution and determinants of the optic cup to disc ratio (CDR) in Malay adults in Singapore.Methods: This population-based, age-stratified study examined 3280 Malay people aged 40 to 80 years in Singapore. Participants underwent a standardized interview and an ocular examination. A slitlamp examination measured the vertical dimensions of the disc and cup, excluding areas of peripapillary atrophy and the Elschnig scleral ring.Results: Vertical CDR was recorded for 3228 right eyes and 3237 left eyes. The mean (SD) CDR was 0.40 (0.15) in both eyes. The CDR in the right eye increased with age (P < .001) and was greater in men vs women (age-adjusted CDR, 0.42 vs 0.39; P < .001). In multiple linear regression, significant determinants of greater CDR were increasing age, male sex, higher intraocular pressure (IOP), lower diastolic blood pressure, lower body mass index, and previous cataract surgery. Of these, higher IOP was the most important determinant of the CDR. After excluding 149 persons with glaucoma, male sex, higher IOP, lower diastolic blood pressure, lower body mass index, and diabetes mellitus were significant predictors of greater CDR.Conclusion: Greater vertical CDR was related to male sex, higher IOP, lower diastolic blood pressure, and lower body mass index.