Allergic and nonallergic forms of atopic diseases
Allergic and nonallergic forms of atopic diseases
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DOI：
10.1067/mai.2003.1595
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发表时间：
2003-08-01
影响因子：
14.2
通讯作者：
Bieber, T
中科院分区：
文献类型：
--
作者：
Novak, N;Bieber, T
特应性皮炎、过敏性鼻炎和哮喘是在复杂遗传背景下发展的特应性疾病，即所谓的特应性素质。虽然它们针对不同的器官，但在大多数患者中，它们的特点是血清总IgE水平升高。然而，在过去的几年里，一组特应性患者表现出正常的IgE水平，并对所谓的“内在”或“非过敏形式”的机制进行了深入的研究。由于特应性疾病研究领域的快速发展，现在首次有可能描述特应性疾病的过敏和非过敏亚型的新的疾病分类，从而为临床医生对这些患者的每个亚组提供更具体的治疗方法带来希望。
Atopic dermatitis, allergic rhinitis, and asthma are atopic diseases that develop on a complex genetic background, the so-called atopic diathesis. Although they target different organs, in most patients they are characterized by the presence of elevated total serum IgE levels. However, a subgroup of atopic patients exhibits normal IgE levels and mechanisms contributing to the so-called "intrinsic" or "nonallergic form" have been the matter of intensive research work in the last years. Because of the rapid advancements in the research field of atopic diseases, it now becomes possible for the first time to delineate a new disease classification of allergic and nonallergic subtypes of atopic diseases, thereby bringing hope to the clinician for a more specific treatment approach for each subgroup of these patients.