Unscheduled apoptosis during acute inflammatory lung injury
Unscheduled apoptosis during acute inflammatory lung injury
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DOI：
10.1038/sj.cdd.4400278
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发表时间：
1997-10-01
影响因子：
12.4
通讯作者：
Horowitz, S
中科院分区：
文献类型：
--
作者：
Mantell, LL;Kazzaz, JA;Horowitz, S
细胞凋亡是目前认为在没有炎症的情况下发生的细胞死亡模式。相反，炎症发生在非预定事件之后，例如导致坏死而不是细胞凋亡的急性组织损伤。我们在三种不同的急性肺损伤模型中检查了这种模式的相关性;高氧、油酸和细菌性肺炎。在每种情况下，发现细胞凋亡实际上是损伤的急性和炎症阶段的重要组成部分。此外，使用对高氧肺损伤不同敏感的小鼠品系，我们观察到凋亡细胞的百分比与肺损伤的严重程度密切相关，这些观察结果表明，细胞凋亡可能是急性损伤期间的生物学后果之一，并且未能去除这些凋亡细胞也可能有助于急性损伤。炎症反应。
Apoptosis is a mode of cell death currently thought to occur in the absence of inflammation, In contrast, inflammation follows unscheduled events such as acute tissue injury which results in necrosis, not apoptosis, We examined the relevance of this paradigm in three distinct models of acute lung injury; hyperoxia, oleic acid, and bacterial pneumonia. In every case, it was found that apoptosis is actually a prominent component of the acute and inflammatory phase of injury, Moreover, using strains of mice that are differentially sensitive to hyperoxic lung injury we observed that the percent of apoptotic cells was well correlated with the severity of lung injury, These observations suggest that apoptosis may be one of the biological consequences during acute injury and the failure to remove these apoptotic cells may also contribute to the inflammatory response.