LOCAL AUTOINOCULATION OF THE SENSITIZED ORGANISM WITH FOREIGN PROTEIN AS A CAUSE OF ABNORMAL REACTIONS
LOCAL AUTOINOCULATION OF THE SENSITIZED ORGANISM WITH FOREIGN PROTEIN AS A CAUSE OF ABNORMAL REACTIONS
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致敏生物体局部自体接种外来蛋白质导致异常反应
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发表时间：
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影响因子：
15.3
通讯作者：
J. Auer
中科院分区：
文献类型：
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作者：
J. Auer
皮肤刺激物二甲苯，当应用于致敏和再注射的兔耳朵时，往往会引起严重的炎症，形成结痂和组织破坏。可能会导致整个耳尖的干性坏疽(图1、2和3)。用相同的剂量和方法，在(1)正常兔，(2)正常兔一次注射马血清(血清对照)，或(3)致敏但不再注射的兔的耳朵上，只引起轻微的炎症，或多或少有一定程度的水肿。炎症和水肿会在2到3天内消失，留下一个几乎正常的耳朵。致敏的再注射兔在应用二甲苯后出现的耳部病变被解释为主要的过敏反应。这种主要的过敏反应被认为是耳部组织局部自体接种循环抗原的结果。局部自体接种是由于木酚的刺激作用，导致应用部位的炎症和浮肿。现在可能会发生过敏反应，因为炎症组织在代谢上比正常组织更活跃，因此炎症细胞每单位时间受到比正常细胞更多的抗原影响。因此，对于非炎症的致敏细胞，阈值下的抗原浓度可能会对炎症的致敏细胞有效。从理论上讲，这一过程可能发生在致敏动物的任何组织中，这些组织可能表现出过敏反应，例如肠、肺、心脏、皮肤、神经、动脉等。这种情况的相互作用可能解释人类受试者的许多功能异常。
The skin irritant, xylol, when applied to the ears of sensitized and reinjected rabbits often causes a severe inflammation with the formation of crusts and destruction of tissue. Dry gangrene of the entire ear tip may result (Figs. 1, 2, and 3). The same agent, applied in the same dosage and in the same way, to the ears of (1) normal rabbits, (2) normal rabbits injected once with horse serum (serum controls), or (3) sensitized but not reinjected rabbits, causes only a mild inflammation with more or less edema. The inflammation and edema disappear in 2 or 3 days, leaving a practically normal ear. The ear lesions of the sensitized reinjected rabbits which develop after the application of xylol are interpreted as a primary anaphylactic reaction. This primary anaphylactic reaction is considered the result of a local autoinoculation of the ear tissues with circulating antigen. The local autoinoculation is brought about by the irritant action of the xylol which causes an inflammation and edema of the site of application. An anaphylactic reaction may now occur because the inflamed tissues are more active metabolically than normal tissues and therefore the inflamed cells are affected by more antigen per unit of time than the normal cells. A subliminal concentration of antigen for non-inflamed, sensitized cells may thus become effective when inflamed sensitized cells are concerned. This process may theoretically occur in any tissue of a sensitized animal which can show an anaphylactic reaction, for example the intestines, lungs, heart, skin, nerves, arteries, etc. It is possible that this interplay of conditions may explain a number of functional abnormalities in the human subject.