Early growth and adult respiratory function in men and women followed from the fetal period to adulthood
Early growth and adult respiratory function in men and women followed from the fetal period to adulthood
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DOI：
10.1136/thx.2006.066241
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发表时间：
2007-05-01
期刊：
影响因子：
10
通讯作者：
Jarvelin, Marjo-Riitta
中科院分区：
文献类型：
--
作者：
Canoy, Dexter;Pekkanen, Juha;Jarvelin, Marjo-Riitta
背景资料：虽然一些研究表明，胎儿生长速度差，如出生体重较低，与儿童期呼吸功能差有关，但成年人的研究结果仍然不一致。进行了一项研究，以确定早期生长和成人呼吸功能之间的关联。方法：一个纵向的出生队列研究进行了5390名男性和女性出生的足月，并前瞻性地从胎儿期到成年。结果：1 s用力呼气容积（FEV 1）和用力肺活量（FVC）均随出生体重的增加而线性增加，但无明显阈值。在调整性别、成年身高和其他潜在混杂因素后，出生体重每增加500 g，FEV 1增加53.1 ml（95% CI 38.4 - 67.7），FVC增加52.5 ml（95% CI 35.5 - 69.4）。这些正相关性在吸烟、身体活动和体重指数等类别中持续存在，其中出生体重较低、吸烟、久坐不动的生活方式或超重的人的呼吸功能最低。婴儿期体重增加与成人期肺功能呈正相关。结论：出生体重与成人期呼吸功能持续且独立相关。有可能的是，早期生命中的生长不良可能会限制正常的肺部生长和发育，这可能会对以后的肺功能产生长期影响。
Background: While some studies suggest that poor fetal growth rate, as indicated by lower birth weight, is associated with poor respiratory function in childhood, findings among adults remain inconsistent. A study was undertaken to determine the association between early growth and adult respiratory function.Methods: A longitudinal birth cohort study was performed of 5390 men and women born full term and prospectively followed from the fetal period to adulthood. Weight at birth and infancy were recorded, and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were assessed by standard spirometry at age 31 years.Results: Adult FEV1 and FVC increased linearly with higher birth weight in both men and women with no apparent threshold. After adjustment for sex, adult height and other potential confounders operating through the life course, every 500 g higher birth weight was associated with a higher FEV1 of 53.1 ml (95% CI 38.4 to 67.7) and higher FVC of 52.5 ml (95% CI 35.5 to 69.4). These positive associations persisted across categories of smoking, physical activity and body mass index, with the lowest respiratory function noted among those with lower birth weight who were smokers, led a sedentary lifestyle or were overweight. Weight gain in infancy was also positively associated with adult lung function.Conclusion: Birth weight is continuously and independently associated with adult respiratory function. It is plausible that poor growth in early life may restrict normal lung growth and development, which could have long-term consequences on lung function later in life.