Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study
Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study
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DOI：
10.1016/j.ctcp.2020.101166
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发表时间：
2020-05-01
影响因子：
3
通讯作者：
Chen, Ying
中科院分区：
文献类型：
--
作者：
Liu, Kai;Zhang, Weitong;Chen, Ying
背景资料：据报道，2019冠状病毒病（COVID-19）患者在呼吸功能、身体功能和心理功能方面存在不同程度的障碍，尤其是老年患者。根据COVID-19患者病情好转和出院的经验，及时的呼吸康复干预可能会改善预后，最大限度地保留功能并提高生活质量（QoL），但全球范围内缺乏探索这种干预结果的研究。目的：探讨6周呼吸康复训练对呼吸功能、生活质量、老年COVID-19患者的活动能力和心理功能。方法：本文报道了一项观察性、前瞻性、准实验性研究的结果，共招募了72名参与者，其中36例患者进行了呼吸康复治疗，其余患者未进行任何康复干预。测量以下结果：肺功能测试，包括体积描记法和一氧化碳弥散肺容量（DLCO），功能测试（6分钟步行距离测试），生活质量（QoL）评估（SF-36评分），日常生活活动（功能独立性测量，Functional Independence Measure，FAI评分）和精神状态测试结果：干预组呼吸康复治疗6周后，FEV 1（L）、FVC（L）、FEV 1/FVC%、DLCO%、6 min步行试验与对照组比较，差异均有统计学意义（P < 0. 05）。SF-36评分在8个维度上，干预组内和两组间均有统计学意义。结论：6周呼吸康复治疗能改善老年COVID-19患者的呼吸功能、生活质量和焦虑情绪，但对老年抑郁症状改善不明显。
Background: Different degrees of disorders are reported in respiratory function, physical function and psychological function in patients with corona virus disease 2019 (COVID-19), especially in elderly patients. With the experience of improved and discharged COVID-19 patients, timely respiratory rehabilitation intervention may improve prognosis, maximize functional preservation and improve quality of life (QoL), but there lacks of studies worldwide exploring the outcome of this intervention.Objective: To investigate the effects of 6-week respiratory rehabilitation training on respiratory function, QoL, mobility and psychological function in elderly patients with COVID-19.Methods: This paper reported the findings of an observational, prospective, quasi-experimental study, which totally recruited 72 participants, of which 36 patients underwent respiratory rehabilitation and the rest without any rehabilitation intervention. The following outcomes were measured: pulmonary function tests including plethysmography and diffusing lung capacity for carbon monoxide (DLCO), functional tests (6-min walk distance test), Quality of life (QoL) assessments (SF-36 scores), activities of daily living (Functional Independence Measure, FIM scores), and mental status tests (SAS anxiety and SDS depression scores).Results: After 6 weeks of respiratory rehabilitation in the intervention group, there disclosed significant differences in FEV1(L), FVC(L), FEV1/FVC%, DLCO% and 6-min walk test. The SF-36 scores, in 8 dimensions, were statistically significant within the intervention group and between the two groups. SAS and SDS scores in the intervention group decreased after the intervention, but only anxiety had significant statistical significance within and between the two groups.Conclusions: Six-week respiratory rehabilitation can improve respiratory function, QoL and anxiety of elderly patients with COVID-19, but it has little significant improvement on depression in the elderly.