Correlation of tear lipid layer interference patterns with the diagnosis and severity of dry eye
Correlation of tear lipid layer interference patterns with the diagnosis and severity of dry eye
复制标题
DOI：
10.1016/s0002-9394(14)70378-2
复制
发表时间：
1996-12-01
影响因子：
4.2
通讯作者：
Kinoshita, S
中科院分区：
文献类型：
--
作者：
Yokoi, N;Takehisa, Y;Kinoshita, S
目的：对正常人和干眼症患者泪膜脂质层干扰图进行观察和分类，探讨干眼症患者泪膜脂质层干扰图与其他干眼检查结果的关系。 方法：对13名正常对照者25只眼和48名干眼症患者85只眼的角膜中央部位进行角膜前泪膜脂质层干扰图的观察。观察到的图案由五名医生以遮蔽方式分为五个等级：1级，颜色略带灰色，分布均匀；1级，颜色略带灰色，分布均匀； 2级，颜色略带灰色，分布不均匀； 3级，颜色少，分布不均匀； 4级，颜色较多，分布不均匀； 5级，角膜表面部分暴露。还进行了其他干眼检查方法，包括棉线试验、Schirmer I 试验和改良 Schirmer I 试验、泪膜破裂时间测量、角膜荧光素染色密度（0 至 3 级）和面积（0 至 3 级）评分以及孟加拉玫瑰染色（0 至 9 级）。 结果：在 110 只眼睛中，有 92 只（84%）眼中，五名医生中的四名或更多同意他们的观点。 等级分类。 92只眼中，正常对照眼分为1级和2级（分别为10只眼和12只眼），干眼分为2、3、4和5级（分别为22、26、10和12只眼）。分级与其他干眼检查方式的结果之间存在显着相关性，包括荧光素染色、孟加拉玫瑰染色和泪膜破裂时间。结论：泪液脂质层干扰模式与干眼严重程度高度相关。
PURPOSE: To observe and classify tear film lipid layer interference patterns in normal volunteers and dry eye patients and to investigate the relation between the lipid layer interference patterns in the dry eyes and the results of other dry eye examinations.METHODS: Precorneal tear lipid layer interference patterns were observed at the central cornea in 25 eyes of 13 normal controls and 85 eyes of 48 dry eye patients. Observed patterns were classified in masked fashion by five physicians into five grades: grade 1, somewhat gray color, uniform distribution; grade 2, somewhat gray color, nonuniform distribution; grade 3, a few colors, nonuniform distribution; grade 4, many colors, nonuniform distribution; and grade 5, corneal surface partially exposed. Other methods of dry eye examination were also performed, including the cotton thread test, the Schirmer I test and modified Schirmer I test, measurement of tear film breakup time, scoring of corneal fluorescein staining density (grades 0 to 3) and area (grades 0 to 3), and rose bengal staining (grades 0 to 9).RESULTS: In 92 (84%) of 110 eyes, four or more of the five physicians agreed in their grade classifications. Among the 92 eyes, normal control eyes were classified into grades 1 and 2 (10 and 12 eyes, respectively) and dry eyes were classified into grades 2, 3, 4, and 5 (22, 26, 10, and 12 eyes, respectively). There was a significant correlation between the grading and the results of other dry eye examination modalities, including fluorescein staining, rose bengal staining, and tear film breakup time.CONCLUSIONS: Tear lipid layer interference patterns are highly correlated with dry eye severity.