Assessment of a single-acquisition imaging sequence for oxygen-sensitive 3He-MRI
Assessment of a single-acquisition imaging sequence for oxygen-sensitive 3He-MRI
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DOI：
10.1002/mrm.10032
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发表时间：
2002-01-01
影响因子：
3.3
通讯作者：
Kauczor, HU
中科院分区：
文献类型：
--
作者：
Deninger, AJ;Eberle, B;Kauczor, HU
使用超极化氦-3（He-3）对肺部进行MRI，可测定肺内氧分压（p（O2））。分离信号损失的竞争过程的需要迄今为止需要在两个不同的呼吸操作期间的两个不同的成像系列。在这项工作中，提出了一种新的成像策略，通过一系列连续扫描来测量p（O2）。该方法的可行性在三个健康的人类志愿者中得到了证实。计算肺内p（O2）的图和直方图。在直方图中很好地再现了吸入气体混合物的氧浓度的变化。肺内3 He超极化的时间演变的蒙特卡罗（MC）模拟进行评估的准确性，这种测量技术，其局限性。Magn Reson Med 47：105-114，2002年。(C)2002 Wiley-Liss，Inc.
MRI of the lungs using hyperpolarized helium-3 (He-3) allows the determination of intrapulmonary oxygen partial pressures (p(O2)). The need to separate competing processes of signal loss has hitherto required two different imaging series during two different breathing maneuvers. In this work, a new imaging strategy to measure p(O2) by a single series of consecutive scans is presented. The feasibility of the method is demonstrated in three healthy human volunteers. Maps and histograms of intrapulmonary p(O2) are calculated. Changes in the oxygen concentration of the inhaled gas mixture are well reproduced in the histograms. Monte Carlo (MC) simulations of the temporal evolution of 3He hyperpolarization within the lungs were performed to evaluate the accuracy of this measurement technique, and its limitations. Magn Reson Med 47:105-114, 2002. (C) 2002 Wiley-Liss, Inc.