Proteomic insights into cardiac cell death and survival.
Proteomic insights into cardiac cell death and survival.
复制标题
对心肌细胞死亡和存活的蛋白质组学见解。
DOI：
10.1002/prca.200780121
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Ping,Peipei
中科院分区：
文献类型：
--
作者：
Maclellan,WRobb;Wang,Yibin;Vondriska,ThomasM;Weiss,JamesN;Ping,Peipei
Cardiovascular disease is the leading cause of death and disability in the developed world. To design novel therapeutic strategies to treat and prevent this disease, better understanding of cardiac cell function is necessary. In addition to (and, indeed, in combination with) genetics, physiology and molecular biology, proteomics plays a critical role in our understanding of cardiovascular systems at multiple scales. The purpose of this review is to examine recent developments in the field of myocardial injury and protection, examining how proteomics has informed investigations into organelles, signaling complexes, and cardiac phenotype.
