A COMPARATIVE-STUDY OF VISUOSPATIAL MEMORY AND LEARNING IN ALZHEIMER-TYPE DEMENTIA AND PARKINSONS-DISEASE
A COMPARATIVE-STUDY OF VISUOSPATIAL MEMORY AND LEARNING IN ALZHEIMER-TYPE DEMENTIA AND PARKINSONS-DISEASE
复制标题
DOI：
10.1093/brain/111.3.695
复制
发表时间：
1988-06-01
期刊：
影响因子：
14.5
通讯作者：
ROBBINS, TW
中科院分区：
文献类型：
--
作者：
SAHAKIAN, BJ;MORRIS, RG;ROBBINS, TW
阿尔茨海默型痴呆（DAT）和特发性帕金森病患者组与年龄和智商匹配的正常对照组一起，在视觉空间记忆和学习的多项计算机化测试中进行了比较。研究了两组不同的帕金森病患者：（1）新诊断组，在病程早期，不接受药物治疗（NMED PD）；（2）一组在病程后期，接受药物治疗（MED PD）。 DAT 和 MED PD 组的空间和视觉模式识别记忆均显着受损。 DAT 组在延迟样本匹配过程中表现出延迟依赖性缺陷（超过 0-16 秒），但在同时样本匹配过程中并未受到损害。相比之下，MED PD 组在延迟样本匹配测试中表现出与延迟无关的缺陷，并且 MED PD 和 NMED PD 组在同时匹配中也显着受损。在延迟反应测试中，受试者首先需要记忆然后学习几个抽象视觉刺激的位置，这些刺激的数量从 1 到 8 个逐渐变化。DAT 组在这项条件联想学习任务中严重受损。 NMED 和 MED PD 组中很大比例的患者（但没有对照组）也未通过 6 或 8 项水平的测试。帕金森病患者的第一次试验表现、延迟反应任务中的记忆评分以及临床残疾指数和疾病持续时间之间存在显着相关性。讨论了 DAT 和 PD 之间的比较在表征这些条件下认知缺陷的性质方面的效用以及它们与使用可比范式的动物神经心理学发现的关系。
Groups of patients with dementia of Alzheimer type (DAT) and idiopathic Parkinson''s disease, together with age and IQ-matched normal controls, were compared on several computerized tests of visuospatial memory and learning. Two different groups of parkinsonian patients were studied: (1) a newly diagnosed group, early in the course of the disease, not receiving medication (NMED PD) and (2) a group later in the course of the disease, receiving medication (MED PD). The DAT and MED PD group were significantly impaired in both spatial and visual pattern recognition memory. The DAT group exhibited a delay-dependent deficit (over 0-16 s) in a delayed matching-to-sample procedure, but were not impaired at simultaneous-matching-to-sample. By contrast, the MED PD group showed delay-independent deficits in the delayed matching-to-sample test and both the MED PD and the NMED PD group were also significantly impaired in simultaneous matching. In a form of delayed response test, the subjects were required first to memorize and then to learn the locations of several abstract visual stimuli which varied progressively in number from 1 to 8. The DAT group were severely impaired in this conditional associative learning task. A significant proportion of patients, but none of the controls, in the NMED and MED PD group also failed the test at the levels of 6 or 8 items. There was a significant correlation between the performance on the first trial, memory score in the delayed response task and indices of clinical disability and disease duration in the patients with Parkinson''s disease. The results are discussed in terms of the utility of the comparison between DAT and PD in characterizing the nature of the cognitive deficits in these conditions and their relation to those findings from animal neuropsychology which use comparable paradigms.