Cerebrospinal Fluid Substance P-Like Immunoreactivity Correlates with Aggression in Personality Disordered Subjects
Cerebrospinal Fluid Substance P-Like Immunoreactivity Correlates with Aggression in Personality Disordered Subjects
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DOI：
10.1016/j.biopsych.2012.02.023
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发表时间：
2012-08-01
影响因子：
10.6
通讯作者：
Nemeroff, Charles B.
中科院分区：
文献类型：
--
作者：
Coccaro, Emil F.;Lee, Royce;Nemeroff, Charles B.
背景：神经化学研究表明多种中枢神经递质在人类攻击行为中具有调节作用；有些似乎发挥抑制作用，而另一些似乎在调节攻击性中发挥促进作用。 P 物质的实验动物研究表明，这种十一肽在调节攻击性方面具有促进作用，但尚未有关于 P 物质与人类攻击性相关的研究报道。 方法：从 38 名患有人格障碍 (PD) 的身体健康受试者中获取基础腰椎脑脊液样本，测量了 P 物质样免疫反应性，并将其与攻击性和攻击性的测量值相关联。 结果：脑脊液 P 类物质免疫反应水平与攻击行为的综合测量直接相关，更具体地说，与 Buss-Durkee 攻击行为直接相关。没有发现任何冲动性或一般人格维度的测量存在相关性。结论：这些数据表明，含有神经回路的中枢神经系统 P 物质与人类受试者的攻击性之间存在直接关系。这一发现增加了人类受试者冲动攻击的中枢神经调节作用的复杂图景。
Background: Neurochemical studies have pointed to a modulatory role in human aggression for a variety of central neurotransmitters; some seem to play an inhibitory role, whereas others seem to play a facilitory role in the modulation of aggression. Laboratory animal studies of substance P suggest a facilitory role for this undecapeptide in the modulation of aggression, but no studies of substance P have yet been reported with regard to human aggression.Methods: Basal lumbar cerebrospinal fluid samples were obtained from 38 physically healthy subjects with personality disorder (PD) and substance P-like immunoreactivity was measured and correlated with measures of aggression and impulsivity.Results: The cerebrospinal fluid substance P-like immunoreactivity levels were directly correlated with a composite measure of aggression and, more specifically, with Buss-Durkee Aggression. No correlation was seen with any measure of impulsivity or of general dimensions of personality.Conclusions: These data suggest a direct relationship between central nervous system substance P containing neural circuits and aggression in human subjects. This finding adds to the complex picture of the central neuromodulatory role of impulsive aggression in human subjects.