Early events regulating immunity and pathogenesis during Listeria monocytogenes infection.

Early events regulating immunity and pathogenesis during Listeria monocytogenes infection.
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DOI:
10.1016/j.it.2012.04.007
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发表时间:
2012-10
影响因子:
16.8
通讯作者:
Lenz LL
Lenz LL
中科院分区:
医学1区
文献类型:
--
作者:
Williams MA;Schmidt RL;Lenz LL

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单核细胞增多性李斯特菌既是一种危及人类生命的病原体,也是一种广泛用于剖析先天性和适应性免疫感染抵抗机制的模式生物。针对全身性 Lm 感染的免疫反应的具体方面可以是保护性的、中性的,或者在某些情况下是有害的。在这篇综述中,我们试图概述 Lm 感染期间决定或调节宿主先天性和适应性免疫反应的早期事件。我们强调了最近的几项进展,这些进展增加了我们对炎症反应、宿主对感染的易感性和保护性免疫发展之间复杂相互作用的理解。
Listeria monocytogenes is both a life-threatening pathogen of humans and a model organism that is widely used to dissect the mechanisms of innate and adaptive immune resistance to infection. Specific aspects of the immune response to systemic Lm infection can be protective, neutral, or in some cases deleterious. In this review, we seek to provide an overview of the early events during Lm infection that dictate or regulate host innate and adaptive immune responses. We highlight several recent developments that add to our understanding of the complex interplay between inflammatory responses, host susceptibility to infection, and the development of protective immunity.
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