Early events regulating immunity and pathogenesis during Listeria monocytogenes infection.
Early events regulating immunity and pathogenesis during Listeria monocytogenes infection.
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DOI:
10.1016/j.it.2012.04.007
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发表时间:
2012-10
影响因子:
16.8
通讯作者:
Lenz LL
中科院分区:
文献类型:
--
作者:
Williams MA;Schmidt RL;Lenz LL
Listeria monocytogenes is both a life-threatening pathogen of humans and a model organism that is widely used to dissect the mechanisms of innate and adaptive immune resistance to infection. Specific aspects of the immune response to systemic Lm infection can be protective, neutral, or in some cases deleterious. In this review, we seek to provide an overview of the early events during Lm infection that dictate or regulate host innate and adaptive immune responses. We highlight several recent developments that add to our understanding of the complex interplay between inflammatory responses, host susceptibility to infection, and the development of protective immunity.
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