A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly
A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly
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DOI：
10.1016/1047-2797(94)00090-g
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发表时间：
1995-01-01
影响因子：
5.6
通讯作者：
Buring, Julie E.
中科院分区：
文献类型：
--
作者：
Gaziano, J. Michael;Manson, Joann E.;Buring, Julie E.
最近的证据表明，氧化损伤可能参与了动脉粥样硬化的形成，因此饮食中的抗氧化剂，如β-胡萝卜素，可能会降低心血管疾病(CVD)的风险。我们调查了1299名老年马萨诸塞州居民食用含胡萝卜素的水果和蔬菜与心血管疾病死亡率之间的关系，这些居民作为马萨诸塞州卫生保健小组研究的一部分提供了饮食信息。在平均4.75年的随访期中，有161人死于心血管疾病，其中48人死于心肌梗死。对于总的心血管疾病死亡和致命的心肌梗死，那些食用含有胡萝卜素的水果和蔬菜的最高四分位数的居民比那些消费最低四分位数的居民风险更低。对于心血管疾病死亡，相对危险度(RR)为0.54(95%可信区间(CI)为0.34至0.86；四分位数趋势的P为0.004)。心肌梗死的相对危险度为0.002.2 5(95%可信区间为0.0 9~0.6 7；趋势P为0.0 5)。这些观察数据与增加饮食中类胡萝卜素的摄入量降低心血管疾病死亡风险的假设是一致的；然而，不能排除混淆。这一假设需要在足够大的随机试验中进行严格的评估，以可靠地检测类胡萝卜素是否通过临床上重要的心血管疾病保护作用提供小到中等程度的保护。
Recent evidence suggests that oxidative damage may be involved in atherogenesis, and thus dietary antioxidants, such as beta-carotene, may reduce the risks of cardiovascular disease (CVD). We examined the association between consumption of carotene-containing fruits and vegetables and CVD mortality among 1299 elderly Massachusetts residents who provided dietary information as a part of the Massachusetts health Care Panel Study. During a mean follow-up of 4.75 years, there were 161 deaths attributable to CVD, 48 of which were due to myocardial infarction. For total CVD death and fatal myocardial infarction, risks were lower among those residents in the highest quartile for consumption of carotene-containing fruits and vegetables as compared with those in the lowest. For death due to CVD, the relative risk (RR) was 0.54 (95% confidence interval (CI), 0.34 to 0.86; P for trend across quartiles, 0.004). For myocardial infarction the RR was 0.25 (95% CI, 0.09 to 0.67; P for trend, 0.002). These observational data are compatible with the hypothesis that increased dietary intake of carotenoids decreases the risks of CVD mortality; however, confounding cannot be ruled out. This hypothesis requires rigorous evaluation in randomized trials of sufficient size to detect reliably whether carotenoids confer small-to-moderate by clinically important protection against CVD.