Melohenines A and B, Two Unprecedented Alkaloids from Melodinus henryi
Melohenines A and B, Two Unprecedented Alkaloids from Melodinus henryi
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DOI：
10.1021/ol9018826
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发表时间：
2009-11-05
期刊：
影响因子：
5.2
通讯作者：
Luo, Xiao-Dong
中科院分区：
文献类型：
--
作者：
Feng, Tao;Cai, Xiang-Hai;Luo, Xiao-Dong
对川楝子（Melodinus henryi）进行了植物化学研究，分离出两种新的生物碱：川楝素A（melohenines A，1）和川楝素B（melohenine B，2）。川楝素A（melohenines A，1）是一种单萜吲哚生物碱，具有额外的八个碳环，而川楝素B（melohenine B，2）是一种具有前所未有的6/9/6/6四环系统的生物碱，被认为是从吲哚到喹啉生物碱的关键中间体。通过光谱法和X-射线衍射分析确定了化合物的结构。
A phytochemical study on Melodinus henryi has led to the Isolation of two novel alkaloids, melohenines A (1), a monoterpenoid indole alkaloid with additional skeletal carbons arranged compactly in eight rings, and melohenine B (2), an alkaloid with an unprecedented 6/9/6/6 tetracyclic ring system regarded as a key intermediate from indole to quinoline alkaloids. Their structures were elucidated by means of spectroscopic methods and further confirmed by X-ray diffraction analysis.