Improvement in outcomes of clinical islet transplantation: 1999-2010.
Improvement in outcomes of clinical islet transplantation: 1999-2010.
复制标题
DOI：
10.2337/dc12-0063
复制
发表时间：
2012-07
期刊：
影响因子：
16.2
通讯作者：
Shapiro AM
中科院分区：
文献类型：
--
作者：
Barton FB;Rickels MR;Alejandro R;Hering BJ;Wease S;Naziruddin B;Oberholzer J;Odorico JS;Garfinkel MR;Levy M;Pattou F;Berney T;Secchi A;Messinger S;Senior PA;Maffi P;Posselt A;Stock PG;Kaufman DB;Luo X;Kandeel F;Cagliero E;Turgeon NA;Witkowski P;Naji A;O'Connell PJ;Greenbaum C;Kudva YC;Brayman KL;Aull MJ;Larsen C;Kay TW;Fernandez LA;Vantyghem MC;Bellin M;Shapiro AM
从合作胰岛移植注册中心(CITR)描述1999至2010年间胰岛移植在伴有严重低血糖的1型糖尿病患者中的主要疗效和安全结局的趋势。对CITR中677例1型糖尿病患者的胰岛移植或移植后胰岛移植患者进行了5项主要疗效和总体安全性分析，以确定早期(1999-2002年)、中期(2003-2006年)或近期(2007-2010年)移植年限的差异，每年随访5年。移植后3年的胰岛素独立性从早期(1999年-2002年)的27%提高到中期(2003年-2006年)的37%和最近时期(2007年-2010年)的44%(P=0.006)。指示胰岛移植物功能的C-肽≥在最近的年代中保留的时间更长(P<；0.001)。HbA1c的降低和严重低血糖的缓解显示出持久的长期效果。空腹血糖稳定在最近时期也显示出改善。不良事件的发生也略有减少。胰岛回输率较低：2007-2010年为48%，而1999-2006年为60-65%(P<；0.01)。曾经获得胰岛素非依赖性的受者胰岛移植功能持续时间更长(P<；0.001)。CITR显示，与1999-2006年相比，2007-2010年接受胰岛移植的受者的主要疗效和安全结果有所改善，每个受者的胰岛输注和不良事件较少。
To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. A total of 677 islet transplant-alone or islet-after-kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999–2002), mid (2003–2006), or recent (2007–2010) transplant era based on annual follow-up to 5 years. Insulin independence at 3 years after transplant improved from 27% in the early era (1999–2002, n = 214) to 37% in the mid (2003–2006, n = 255) and to 44% in the most recent era (2007–2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function, was retained longer in the most recent era (P < 0.001). Reduction of HbA1c and resolution of severe hypoglycemia exhibited enduring long-term effects. Fasting blood glucose stabilization also showed improvements in the most recent era. There were also modest reductions in the occurrence of adverse events. The islet reinfusion rate was lower: 48% by 1 year in 2007–2010 vs. 60–65% in 1999–2006 (P < 0.01). Recipients that ever achieved insulin-independence experienced longer duration of islet graft function (P < 0.001). The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007–2010 compared with those in 1999–2006, with fewer islet infusions and adverse events per recipient.
登录
查看更多内容
影响因子：
8.8
作者：
Bellin, M. D.;Kandaswamy, R.;Hering, B. J.
通讯作者：
Hering, B. J.
影响因子：
7.7
作者：
Deng, SP;Vatamaniuk, M;Markmann, JF
通讯作者：
Markmann, JF
影响因子：
6.2
作者：
Cardani, Roberta;Pileggi, Antonello;Alejandro, Rodolfo
通讯作者：
Alejandro, Rodolfo
影响因子：
16.2
作者：
Maffi, Paola;Caumo, Andrea;Secchi, Antonio
通讯作者：
Secchi, Antonio
影响因子：
7.7
作者：
Johansson, H;Lukinius, A;Nilsson, B
通讯作者：
Nilsson, B