Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis.
Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis.
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发表时间：
1998-04
期刊：
影响因子：
11.2
通讯作者：
Vincent W. Yang;J. M. Shields;Stanley R. Hamilton;Ernst W. Spannhake;Walter C. Hubbard;L. Hylind;C. Robinson;F. Giardiello
中科院分区：
文献类型：
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作者：
Vincent W. Yang;J. M. Shields;Stanley R. Hamilton;Ernst W. Spannhake;Walter C. Hubbard;L. Hylind;C. Robinson;F. Giardiello
最近的研究表明，非甾体抗炎药对结直肠肿瘤具有化学预防作用。非甾体抗炎药抑制环氧合酶，这是介导前列腺素形成的主要酶。为了确定前列腺素是否参与结直肠腺瘤的发病机制，我们比较了正常粘膜和家族性腺瘤性息肉病患者腺瘤中环氧合酶途径的五种主要稳定代谢产物的水平。在接受测试的 12 名患者中，有 6 名患者的腺瘤中至少一种前列腺素水平升高。更重要的是，与同一患者的正常粘膜相比，腺瘤中三种前列腺素[前列腺素 (PG)D2、PGE2 和 6-keto-PGF1α] 的相对水平升高，并且所得比率与腺瘤的大小相关。这些结果表明前列腺素类药物在家族性腺瘤性息肉病患者的结直肠息肉病进展中发挥作用。
Recent studies indicate that nonsteroidal anti-inflammatory drugs have a chemopreventive effect against colorectal neoplasia. Nonsteroidal anti-inflammatory drugs inhibit cyclooxygenases, principal enzymes that mediate the formation of prostanoids. To determine whether prostanoids are involved in the pathogenesis of colorectal adenomas, we compared the levels of five major stable metabolic products of the cyclooxygenase pathway in the normal-appearing mucosa and in adenomas of patients with familial adenomatosis polyposis. Of 12 patients tested, 6 had elevated levels of at least one prostanoid in the adenomas. More importantly, the relative levels of three prostanoids [prostaglandin (PG)D2, PGE2, and 6-keto-PGF1alpha] were elevated in adenomas compared to normal-appearing mucosa from the same patients, and the resulting ratios were correlated with the size of the adenoma. These results suggest a role for prostanoids in progression of colorectal polyposis in familial adenomatosis polyposis patients.