Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography
Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography
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DOI：
10.1016/j.jcrs.2014.03.017
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发表时间：
2014-06-01
影响因子：
2.8
通讯作者：
Dupps, William J., Jr.
中科院分区：
文献类型：
--
作者：
Ford, Matthew R.;Roy, Abhijit Sinha;Dupps, William J., Jr.
目的：无创评估角膜水合和胶原交联 (CXL) 对角膜机械行为的影响。地点：美国俄亥俄州克利夫兰克利夫兰诊所科尔眼科研究所。设计：实验研究。方法：使用光学相干弹性成像 (OCE) 技术测量 5 对摘除的人类供体眼球在以下 3 个系列状态下的位移行为：水肿、正常厚度和厚度。核黄素紫外线A介导的CXL之后。在生理眼压 (IOP) 下使用弯曲角镜片进行微电机控制的轴向位移期间，获得连续光学相干断层扫描，以允许在角膜中央 4.0 mm 上进行高分辨率基质内散斑跟踪和位移测量。 结果：在 IOP 没有强制增加的情况下，平均横向与强制轴向位移比率为 0.035 μ m/μm +/- 0.037 (SD)水肿角膜，正常厚度角膜为 0.021 +/- 0.02 μm/μm，CXL 后角膜为 0.014 +/- 0.009 μm/μm。差异有统计学意义（P
PURPOSE: To noninvasively evaluate the effects of corneal hydration and collagen crosslinking (CXL) on the mechanical behavior of the cornea.SETTING: Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, USA.DESIGN: Experimental study.METHODS: An optical coherence elastography (OCE) technique was used to measure the displacement behavior of 5 pairs of debrided human donor globes in 3 serial states as follows: edematous, normal thickness, and after riboflavin ultraviolet-A mediated CXL. During micromotor-controlled axial displacements with a curved goniolens at physiologic intraocular pressure (IOP), serial optical coherence tomography scans were obtained to allow high-resolution intrastromal speckle tracking and displacement measurements over the central 4.0 mm of the cornea.RESULTS: With no imposed increase in IOP, the mean lateral to imposed axial displacement ratios were 0.035 mu m/mu m +/- 0.037 (SD) in edematous corneas, 0.021 +/- 0.02 mu m/mu m in normal thickness corneas, and 0.014 +/- 0.009 mu m/mu m in post-CXL corneas. The differences were statistically significant (P