Baroreflex control of heart rate in a canine model of obstructive sleep apnea
Baroreflex control of heart rate in a canine model of obstructive sleep apnea
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DOI：
10.1164/ajrccm.159.4.9806114
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发表时间：
1999-04-01
影响因子：
24.7
通讯作者：
Phillipson, EA
中科院分区：
文献类型：
--
作者：
Brooks, D;Horner, RL;Phillipson, EA
我们最近在阻塞性睡眠呼吸暂停（OSA）犬模型中证明了系统性高血压的发展，但尚未确定潜在的生理机制。因此，本研究的目的是检查 OSA 对犬模型中动脉压力感受器控制心率 (HR) 的影响。三只狗产生 OSA，持续 1 至 3 个月。通过在 30 至 60 秒内分级输注血管活性药物（去氧肾上腺素和硝普钠）来确定 HR 的压力感受反射控制，在此期间记录稳态收缩压 (BP) 和心脏 R-R 间期反应。血压是通过永久植入的动脉导管和遥测系统测量的。尽管如之前报道的那样，OSA 导致白天（清醒）平均血压增加 6.0 至 26.8 mm Hg，但白天基线 HR 或收缩压-R-R 间期曲线的斜率没有变化 (p > 0.2)。研究结果表明，狗的 OSA 与压力感受器重置至较高压力有关，但压力反射敏感性没有变化。
We have recently demonstrated the development of systemic hypertension in a canine model of obstructive sleep apnea (OSA), but the underlying physiological mechanisms were not identified. Therefore, the purpose of this study was to examine the effect of OSA on arterial baroreceptor control of heart rate (HR) in this canine model. OSA was produced in three dogs for 1 to 3 mo. Baroreflex control of HR was determined with graded infusions of vasoactive agents (phenylephrine and nitroprusside) administered over 30 to 60 s, during which steady-state systolic blood pressure (BP) and cardiac R-R interval responses were recorded. BP was measured with a permanently implanted arterial catheter and a telemetry system. Although, as previously reported, OSA resulted in increases in daytime (awake) mean BP of 6.0 to 26.8 mm Hg, there was no change in daytime baseline HR or in the slope of the systolic BP-R-R interval curve (p > 0.2). The findings demonstrate that OSA in the dog is associated with resetting of the baroreceptors to a higher pressure, but no change in baroreflex sensitivity.