Surgical outcomes of 2041 consecutive laparoscopic gastrectomy procedures for gastric cancer: a large-scale case control study.
Surgical outcomes of 2041 consecutive laparoscopic gastrectomy procedures for gastric cancer: a large-scale case control study.
复制标题
DOI：
10.1371/journal.pone.0114948
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Lin M
中科院分区：
文献类型：
--
作者：
Lin JX;Huang CM;Zheng CH;Li P;Xie JW;Wang JB;Lu J;Chen QY;Cao LL;Lin M
腹腔镜胃切除术（LG）的胃癌越来越受欢迎，由于手术技术的进步。本研究的目的是验证腹腔镜胃切除术与开腹胃切除术（OG）相比治疗胃癌的有效性和安全性。该研究包括2005年1月至2013年10月期间通过腹腔镜胃切除术（2，041例患者）或开放式胃切除术（1，539例患者）进行根治性治疗的3，580例患者。比较两组手术效果。腹腔镜胃切除术与开腹胃切除术相比，失血量、输血患者数量、地面活动时间和术后住院时间显著减少，但手术时间、首次排气时间和恢复饮食时间相似。两组间淋巴结清扫数量无显著差异。LG组的发病率和死亡率与OG组相当（13.6% vs. 14.4%，P = 0.526和0.3% vs. 0.2%，P = 0.740）。两组3年无瘤生存率和总生存率比较差异有统计学意义（P<0.05）。按照UICC胃癌TNM分期，各期3年无瘤生存率和总生存率差异无统计学意义。我们的一项大型患者系列的单中心研究显示，LG治疗胃癌的手术结局相当。这一结果也适用于局部进展期胃癌（AGC）。可以进行一项设计良好的随机对照试验，在大量AGC患者中比较LG和OG的手术结局。
Laparoscopic gastrectomy (LG) for gastric cancer has increased in popularity due to advances in surgical techniques. The aim of this study is to validate the efficacy and safety of laparoscopic gastrectomy for gastric cancer compared with open gastrectomy (OG). The study comprised 3,580 patients who were treated with curative intent either by laparoscopic gastrectomy (2,041 patients) or open gastrectomy (1,539 patents) between January 2005 and October 2013. The surgical outcomes were compared between the two groups. Laparoscopic gastrectomy was associated with significantly less blood loss, transfused patient number, time to ground activities, and post-operative hospital stay, but with similar operation time, time to first flatus, and time to resumption of diet, compared with the open gastrectomy. No significant difference in the number of lymph nodes dissected was observed between these two groups. The morbidity and mortality rates of the LG group were comparable to those of the OG group (13.6% vs. 14.4%, P = 0.526, and 0.3% vs. 0.2%, P = 0.740). The 3-year disease-free and overall survival rates between the two groups were statistically significant (P<0.05). According to the UICC TNM classification of gastric cancer, the 3-year disease-free and overall survival rates were not statistically different at each stage. Our single-center study of a large patient series revealed that LG for gastric cancer yields comparable surgical outcomes. This result was also true of local advanced gastric cancer (AGC). A well-designed randomized controlled trial comparing surgical outcomes between LG and OG in a larger number of patients for AGC can be carried out.
登录
查看更多内容
影响因子：
3.2
作者：
Bo, T.;Peiwu, Y.;Huaxing, L.
通讯作者：
Huaxing, L.
影响因子：
3.2
作者：
Lin JX;Huang CM;Zheng CH;Li P;Xie JW;Wang JB;Lu J
通讯作者：
Lu J
影响因子：
9
作者：
Kitano, Seigo;Shiraishi, Norio;Tanigawa, Nobuhiko
通讯作者：
Tanigawa, Nobuhiko
DOI：
10.1007/s00464-008-0198-0
发表时间：
2009-08-01
影响因子：
3.1
作者：
Lee, Joo-Ho;Yom, Cha-Kyong;Han, Ho-Seong
通讯作者：
Han, Ho-Seong
影响因子：
2.5
作者：
Kim, Ki Han;Kim, Min Chan;Kim, Hyung Ho
通讯作者：
Kim, Hyung Ho