Alternative splicing of DNA damage response genes and gastrointestinal cancers
Alternative splicing of DNA damage response genes and gastrointestinal cancers
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DOI：
10.3748/wjg.v20.i46.17305
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发表时间：
2014-12-14
影响因子：
4.3
通讯作者：
Nomura, Fumio
中科院分区：
文献类型：
--
作者：
Rahmutulla, Bahityar;Matsushita, Kazuyuki;Nomura, Fumio
选择性剪接是哺乳动物基因组中的一种常见现象，是基因调控的一个基本过程，并有助于丰富蛋白质多样性。选择性剪接事件不仅发生在正常的基因调控过程中，而且与包括癌症在内的某些疾病密切相关。本文简要介绍了选择性剪接和DNA损伤的概念，阐述了选择性剪接与肿瘤发病机制的关系，重点介绍了选择性剪接、DNA损伤和胃肠道肿瘤的潜在关系。我们还将讨论选择性剪接是否会导致遗传不稳定性，这被认为是肿瘤发生的驱动力。深入了解选择性剪接在肿瘤发生中的作用和机制可能为今后的肿瘤研究提供新的方向。(C)2014百世登出版集团股份有限公司All rights reserved.
Alternative splicing, which is a common phenomenon in mammalian genomes, is a fundamental process of gene regulation and contributes to great protein diversity. Alternative splicing events not only occur in the normal gene regulation process but are also closely related to certain diseases including cancer. In this review, we briefly demonstrate the concept of alternative splicing and DNA damage and describe the association of alternative splicing and cancer pathogenesis, focusing on the potential relationship of alternative splicing, DNA damage, and gastrointestinal cancers. We will also discuss whether alternative splicing leads to genetic instability, which is considered to be a driving force for tumorigenesis. Better understanding of the role and mechanism of alternative splicing in tumorigenesis may provide new directions for future cancer studies. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.