Crosstalk between ferroptosis and stress-Implications in cancer therapeutic responses.
Crosstalk between ferroptosis and stress-Implications in cancer therapeutic responses.
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铁死亡和压力之间的串扰——对癌症治疗反应的影响
DOI：
10.1002/cai2.7
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发表时间：
2022-06
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铁凋亡是一种新发现的细胞死亡形式，其特征在于铁依赖性脂质过氧化的积累。在过去的几年里，对铁凋亡的研究呈指数增长。肿瘤细胞的生长强烈依赖于铁，这使得它们发展出增加铁摄取和抑制铁输出的机制，从而完成铁积累。铁凋亡可被各种应激通过多种机制诱导或抑制，使其处于应激相关癌细胞命运决定的十字路口。在这篇综述中，我们简要总结了铁凋亡的标志，并提供了一个系统的分析目前的分子机制和不同的压力条件下对铁凋亡的调控网络。我们还讨论了铁凋亡和癌症治疗反应之间的关系，以进一步了解癌症治疗的潜在靶点和治疗策略。这篇综述总结了铁凋亡的特点，讨论了铁凋亡如何通过多种外在或内在的压力进行调节，并强调了铁凋亡和癌症治疗反应之间的相互联系。更好地了解铁凋亡的复杂调控网络及其与当前疗法的相互作用，最终有助于开发新的癌症治疗方法
Ferroptosis is a newly discovered form of cell death that is characterized by the accumulation of iron‐dependent lipid peroxidation. Research on ferroptosis has seen exponential growth over the past few years. Tumor cells are strongly dependent on iron for their growth, which makes them develop mechanisms to increase iron uptake and inhibit iron output, thereby completing iron accumulation. Ferroptosis can be induced or inhibited by various stresses through multiple mechanisms, making it stands at the crossroads of stresses related cancer cell fate determination. In this review, we give a brief summary of ferroptosis hallmarks and provide a systematic analysis of the current molecular mechanisms and regulatory networks of diverse stress conditions on ferroptosis. We also discuss the relationships between ferroptosis and cancer therapy responses to further understand potential targets and therapeutic strategies for cancer treatment. This review summarizes the hallmarks of ferroptosis, discusses how ferroptosis can be modulated by multiple extrinsic or intrinsic stresses, and highlights the interconnection between ferroptosis and cancer therapy response. A better understanding of the complex regulatory networks of ferroptosis and its interplay with current therapies could ultimately help to develop novel therapeutic approaches against cancer