Signaling Pathways that Regulate Cell Division
Signaling Pathways that Regulate Cell Division
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DOI：
10.1101/cshperspect.a005942
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发表时间：
2012-10-01
影响因子：
7.2
通讯作者：
Russell, Paul
中科院分区：
文献类型：
--
作者：
Rhind, Nicholas;Russell, Paul
细胞分裂需要仔细协调三个主要事件：进入有丝分裂、染色体分离和胞质分裂。控制这些事件的分子内部和之间的信号传递允许它们通过检查点进行协调，检查点是一类特定的信号通路，确保细胞周期事件依赖于先前事件的成功完成。多个正反馈和负反馈循环确保细胞完全致力于分裂，并确保事件以正确的顺序发生。与其他信号通路不同，其他信号通路整合外部输入来决定是否执行给定的过程，细胞分裂时的信号主要致力于完成G1期的决定-启动并完成一轮有丝分裂细胞分裂。这些信号通路不是决定细胞分裂事件是否会发生，而是将这些事件牵涉到细胞周期激酶细胞周期蛋白依赖激酶1(CDK1)的激活，并为检查点蛋白提供机会，在出现问题时阻止细胞分裂。
Cell division requires careful orchestration of three major events: entry into mitosis, chromosomal segregation, and cytokinesis. Signaling within and between the molecules that control these events allows for their coordination via checkpoints, a specific class of signaling pathways that ensure the dependency of cell-cycle events on the successful completion of preceding events. Multiple positive- and negative-feedback loops ensure that a cell is fully committed to division and that the events occur in the proper order. Unlike other signaling pathways, which integrate external inputs to decide whether to execute a given process, signaling at cell division is largely dedicated to completing a decision made in G1 phase-to initiate and complete a round of mitotic cell division. Instead of deciding if the events of cell division will take place, these signaling pathways entrain these events to the activation of the cell-cycle kinase cyclin-dependent kinase 1 (CDK1) and provide the opportunity for checkpoint proteins to arrest cell division if things go wrong.