Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application
Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application
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DOI：
10.1364/oe.20.007954
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发表时间：
2012-03-26
期刊：
影响因子：
3.8
通讯作者：
Sudbo, Aasmund S.
中科院分区：
文献类型：
--
作者：
Grepstad, Jon Olav;Kaspar, Peter;Sudbo, Aasmund S.
介绍了一种用于生物分子检测的传感器。该传感器利用具有亚微米厚度和通孔的平面2D光子晶体(PC)膜来诱导高光场，从而能够检测到小于光学显微镜衍射极限的纳米颗粒。我们报道了我们设计和制备的一种纳米颗粒包裹在其中的PC膜。我们还设计和建造了一个成像系统，其中使用光学显微镜和CCD摄像机来拍摄PC膜的图像。结果显示，捕获的纳米粒子如何在图像中显示为一个亮点。在成像系统的第一个实验实现中，可以检测到半径为75 nm的单个粒子。(C)2012年美国光学学会
A sensor designed to detect bio-molecules is presented. The sensor exploits a planar 2D photonic crystal (PC) membrane with sub-micron thickness and through holes, to induce high optical fields that allow detection of nano-particles smaller than the diffraction limit of an optical microscope. We report on our design and fabrication of a PC membrane with a nano-particle trapped inside. We have also designed and built an imaging system where an optical microscope and a CCD camera are used to take images of the PC membrane. Results show how the trapped nano-particle appears as a bright spot in the image. In a first experimental realization of the imaging system, single particles with a radius of 75 nm can be detected. (C) 2012 Optical Society of America