Knowledge and perceptions of BRCA1/2 genetic testing and needs of diverse women with a personal or family history of breast cancer in South Florida.
Knowledge and perceptions of BRCA1/2 genetic testing and needs of diverse women with a personal or family history of breast cancer in South Florida.
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南佛罗里达州有乳腺癌个人或家族史的不同女性对 BRCA1/2 基因检测的知识和看法以及需求。
DOI：
10.1007/s12687-021-00507-6
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发表时间：
2021
影响因子：
1.9
通讯作者：
Underhill-Blazey,Meghan
中科院分区：
文献类型：
--
作者：
Jones,Tarsha;Howard,Heather;Freeman-Costin,Katherine;Creighton,Ana;Wisdom-Chambers,Karen;Underhill-Blazey,Meghan
绝大多数（BRCA 1/2）基因检测是在白色妇女，特别是德系犹太妇女中进行的，黑人和西班牙裔妇女的信息有限。了解那些得不到充分服务的人的观点对于制定干预措施以支持包容性的基因检测方法至关重要。这项定性研究探讨了知识和观念的BRCA 1/2基因检测在不同的妇女在南佛罗里达。我们还探讨了参与者的信息需求。采用方便抽样方法，招募了一组15名有乳腺癌个人或家族史的妇女。我们进行了半结构式访谈，并使用扎根理论方法对数据进行了分析。确定了五个主题：（1）缺乏对黑人妇女BRCA 1/2基因检测和结果的认识和了解，（2）认为BRCA 1/2基因检测对自己有益，是一种积极主动地预防癌症风险的方法，（3）认为BRCA 1/2基因检测对家庭成员有益，（4）与医疗保健提供者和医疗保健系统的互动，塑造了基因检测的经验，（5）降低癌症风险和促进健康的信息需求。我们的研究结果表明，不同的服务不足的妇女认为基因检测对自己和家庭成员有益。女性需要更多关于BRCA基因和基因检测、预防策略以及最新乳腺癌研究的信息。医疗保健提供者，特别是护士从业者，需要让不同的高风险妇女参与讨论他们的癌症风险，解决未满足的信息需求，特别是教育黑人妇女进行基因检测的好处。
The vast majority of (BRCA1/2) genetic testing has been conducted in White women, in particular Ashkenazi Jewish women, with limited information available for Black and Hispanic women. Understanding perspectives of those who are underserved is critical to developing interventions to support inclusive approaches to genetic testing. This qualitative study explored knowledge and perceptions ofBRCA1/2genetic testing among diverse women in South Florida. We also explored participants’ information needs. Convenience sampling was used to recruit a diverse group of 15 women with a personal or family history of breast cancer. We conducted semi-structured interviews and used grounded theory method to analyze the data. Five themes were identified: (1) lacking awareness and knowledge ofBRCA1/2genetic testing and results among Black women, (2) perceivingBRCA1/2genetic testing as beneficial to themselves and a way to be proactive about cancer risk, (3) perceivingBRCA1/2genetic testing as beneficial to family members, (4) interactions with healthcare providers and the healthcare system that shape genetic testing experiences, and (5) information needs for reducing cancer risk and promoting health. Our findings suggest that diverse underserved women perceived genetic testing as beneficial to themselves and family members. Women needed more information about theBRCAgenes and genetic testing, prevention strategies, and the latest breast cancer research. Healthcare providers, particularly nurse practitioners, need to engage diverse high-risk women in discussions about their cancer risk, address unmet information needs, and, in particular, educate Black women about the benefits of pursuing genetic testing.