Cuticular drusen: Stars in the sky
Cuticular drusen: Stars in the sky
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DOI：
10.1016/j.preteyeres.2013.08.003
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发表时间：
2013-11-01
影响因子：
17.8
通讯作者：
Klevering, B. Jeroen
中科院分区：
文献类型：
--
作者：
Boon, Camiel J. F.;van de Ven, Johannes P. H.;Klevering, B. Jeroen
角质层结节是年龄相关性黄斑变性（AMD）的一种特殊临床亚型。与普通AMD人群相比，该亚型AMD发病年龄更早，家族性成分更强，遗传因素在其发展中起着更突出的作用。在这篇综述中，我们描述了角质层性肾小球肾炎的临床特征和鉴别诊断，以及与II型膜增生性肾小球肾炎的全身关联。我们讨论了最近的遗传和病理生理学的见解，并强调了未来的治疗观点。(C) 2013 Elsevier Ltd.版权所有。
Cuticular drusen is a specific clinical subtype of age-related macular degeneration (AMD). This subtype of AMD has an earlier age at onset, a stronger familial component, and genetic factors play a more prominent role in its development than in the general AMD population. In this review, we describe the clinical characteristics and differential diagnosis of cuticular drusen, as well as systemic associations including membranoproliferative glomerulonephritis type II. We discuss recent genetic and pathophysiological insights, and future therapeutic perspectives are highlighted. (C) 2013 Elsevier Ltd. All rights reserved.