Eczema, birth order, and infection
Eczema, birth order, and infection
复制标题
DOI：
10.1093/aje/kwn042
复制
发表时间：
2008-05-15
影响因子：
5
通讯作者：
Roman, Eve
中科院分区：
文献类型：
--
作者：
Hughes, Ann Maree;Crouch, Simon;Roman, Eve
在1991-1996年期间在英国进行的一项全国性基于人群的病例对照研究中，对1,782名对照儿童进行了调查，以研究出生后头2年发生的感染与湿疹发生之间的关系。湿疹和感染诊断的日期从同期收集的初级保健记录中确定。2岁以前诊断为湿疹的儿童比没有湿疹的儿童有更多的既往临床诊断感染记录（率比= 1.26，95%置信区间（CI）：1.18，1.36）。有湿疹和没有湿疹的儿童之间的感染率差异从出生到生命的前2年都很明显。正如预期的那样，与第二胎或更高胎的孩子相比，第一胎的孩子患湿疹的风险增加（p = 0.020）;然而，湿疹和既往感染之间的关系仅在第二胎或更高胎的孩子中明显，而在第一胎的孩子中不明显（率比分别为1.45，95%CI：1.32，1.59;率比分别为1.08，95%CI：0.98，1.20）。作者的结果与出生顺序和湿疹之间的联系不太可能归因于早期感染暴露的变化的观点一致。
The association between infections occurring in the first 2 years of life and development of eczema was investigated in 1,782 control children from a national population-based case-control study in the United Kingdom conducted over the period 1991-1996. Dates of eczema and infectious diagnoses were ascertained from contemporaneously collected primary care records. Children diagnosed with eczema before the age of 2 years had more prior clinically diagnosed infections recorded than did children without eczema (rate ratio = 1.26, 95% confidence interval (CI): 1.18, 1.36). The difference in infection rates between children with and without eczema was apparent from birth and throughout the first 2 years of life. As expected, compared with children of second or higher birth order, those firstborn were at increased risk of eczema (p = 0.020); however, the relation between eczema and prior infection was evident only among children of second or higher birth order and not among firstborn children (rate ratio = 1.45, 95% CI: 1.32, 1.59, and rate ratio = 1.08, 95% CI: 0.98, 1.20, respectively). The authors' results are consistent with the notion that the association between birth order and eczema is unlikely to be attributable to variations in early infectious exposure.