Voriconazole in fungal keratitis caused by Scedosporium apiospermum
Voriconazole in fungal keratitis caused by Scedosporium apiospermum
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DOI：
10.1345/aph.1d128
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发表时间：
2004-03-01
影响因子：
2.9
通讯作者：
Baines, JPO
中科院分区：
文献类型：
--
作者：
Prats, CH;Tello, FL;Baines, JPO
目的：据我们所知，描述第一例用全身和局部伏立康唑成功治疗的外伤后 Scedosporium apiospermum (ScA) 角膜炎。 病例摘要：一名 19 岁男子因左眼切伤入院，角膜在园艺用刀具外伤后被完全切开。最初的经验性治疗随后是全身和局部伏立康唑，并且不必摘除眼睛。外伤后五个月，进行了穿透性角膜移植术和房型人工晶状体植入术，视力结果良好。讨论：ScA 角膜炎很少见，但如果存在被污染物体造成眼部损伤的病史，则必须怀疑。在可用于治疗 ScA 角膜炎的抗真菌药物中，伏立康唑显示出多种优势，例如最低抑菌浓度和口服制剂的可用性。 结论：伏立康唑有望成为治疗 ScA 角膜炎的传统抗真菌药物的有效替代品。它有口服和静脉注射制剂两种形式，这对于这些长期感染来说是一个很大的优势。
OBJECTIVE: To describe the first case, to the best of our knowledge, of posttraumatic Scedosporium apiospermum (ScA) keratitis successfully treated with systemic and topical voriconazole.CASE SUMMARY: A 19-year-old man was admitted to the hospital with an incisive wound of his left eye and the cornea totally sectioned after trauma with a cutter used in gardening. Initial empirical treatment was followed by systemic and topical voriconazole, and the eye did not have to be enucleated. Five months after the trauma, a penetrating keratoplasty and chamber intraocular lens implantation was performed with a favorable visual outcome.DISCUSSION: ScA keratitis is rare, but it must be suspected if a history of ocular injury with contaminated objects exists. Among the antifungals available to treat ScA keratitis, voriconazole has shown advantages such as the lowest minimum inhibitory concentration and the availability of an oral formulation.CONCLUSIONS: Voriconazole shows promise as an effective alternative to conventional antifungals in the treatment of ScA keratitis. It is available both as oral and intravenous preparations, which is a great advantage in these lengthy infections.