Subjective and objective responses to ethanol in moderate/heavy and light social drinkers
Subjective and objective responses to ethanol in moderate/heavy and light social drinkers
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DOI：
10.1097/00000374-200006000-00007
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发表时间：
2000-06-01
影响因子：
3.2
通讯作者：
de Wit, H
中科院分区：
文献类型：
--
作者：
Holdstock, L;King, AC;de Wit, H
背景资料：大量饮酒的人因饮酒而产生不良后果的风险增加，并且他们的饮酒习惯会发展为滥用或依赖。因此，重要的是要划定与他们的大量drinking.Methods的因素：我们研究了个体差异的主观和客观的反应，乙醇与消费水平的重新分析数据，从9个最重和9个最轻的社会饮酒者从两个独立收集的受试者样本：Holdstock和德威特（1998年）和国王等人。（1997年）。两个样本中的轻度饮酒者每周饮用5杯或更少的酒精饮料，而中度/重度饮酒者每周饮用8杯或更多的酒精饮料，并经常狂欢。急性主观和客观的反应，乙醇（0.6或0.8克/公斤）或安慰剂进行了比较，在两组在基线和上升和下降的血液酒精concentration.Results：中度/重度饮酒者报告更大的兴奋剂样和更少的镇静剂样和厌恶的主观效果后，乙醇比轻饮酒者。这些差异发生在没有任何组的差异呼吸酒精水平，性能的影响，或神经内分泌的变化，或在整体报告的感觉任何药物effects.Conclusions：这些数据表明，习惯性的中度/heaty乙醇的使用与更大的兴奋剂样作用后，急性剂量的酒精。这一发现与以下观点一致（Newlin和Thomson，1990，1999），即在血液酒精浓度曲线的上升段经历更大的兴奋剂样作用而在下降段经历更小的镇静剂样作用的个体可能具有更大的发生乙醇使用障碍的风险。虽然我们不能确定这种关联的因果关系，但对乙醇刺激作用的敏感性可能在继续大量使用乙醇和增加使用乙醇的负面后果风险方面发挥重要作用。
Background: Individuals who drink heavily are at an increased risk for adverse consequences of drinking and progression of their drinking habits to abuse or dependence. Therefore, it is important to delineate factors associated with their heavy drinking.Methods: We examined individual differences in subjective and objective responses to ethanol associated with level of consumption by reanalyzing data from the nine heaviest and nine lightest social drinkers from each of two independently collected subject samples: Holdstock and de Wit (1998) and King et al. (1997). The light drinkers in both samples consumed five or less alcoholic drinks per week, whereas the moderate/heavy drinkers consumed eight or more drinks per week with frequent binge episodes. Acute subjective and objective responses to ethanol (0.6 or 0.8 g/kg) or placebo were compared in the two groups at baseline and during rising and falling blood alcohol concentrations.Results: Moderate/heavy drinkers reported greater stimulant-like and fewer sedative-like and aversive subjective effects after ethanol than did lighter drinkers. These differences occurred in the absence of any group differences in breath alcohol levels, performance effects, or neuroendocrine changes or in overall reports of feeling any drug effects.Conclusions: These data indicate that habitual moderate/heaty ethanol use was associated with greater stimulant-like effects after an acute dose of alcohol. This finding is consistent with the idea (Newlin and Thomson, 1990, 1999) that individuals who experience greater stimulant-like effects during the ascending limb and lesser sedative-like effects on the descending limb of the blood alcohol concentration curve may be at greater risk for developing ethanol use disorders. Although we cannot determine the causality of this association, sensitivity to the stimulant effects of ethanol may play an important role in the continuation of heavy ethanol use and the increased risk of negative consequences from this use.