Glycopolymer Preparation via Post-Polymerization Modification using N-succinimidyl Monomers
Glycopolymer Preparation via Post-Polymerization Modification using N-succinimidyl Monomers
复制标题
使用 N-琥珀酰亚胺基单体进行聚合后改性制备糖聚合物
DOI：
10.1038/s41428-019-0170-y
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Yoshiko Miura
中科院分区：
文献类型：
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作者：
Tomohiro Fukuda;Sotaro Tsuji;Yoshiko Miura
以N-甲基丙烯酰氧基琥珀酰亚胺（MASI）和N-丙烯酰氧基琥珀酰亚胺（ASI）等N-琥珀酰亚胺基单体作为预聚物，通过后聚合改性合成糖聚合物。 RAFT 试剂的活性自由基聚合不仅使用 MASI，而且使用 ASI 也取得了成功。虽然使用 ASI 时 ATRP 引发剂的聚合没有成功，但使用 MASI 时聚合过程成功。 MASI 也适用于基材表面上的 SI-ATRP 反应。通过胺偶联反应将NH2封端的糖引入到预聚物上的速率受到反应温度的影响。这种通过后聚合修饰的制备过程有望为各种功能聚合物（例如其他糖和有益配体）提供简便的方法。
N-succinimidyl monomers such asN-methacryloxysuccinimide (MASI) andN-acryloxysuccinimide (ASI) were utilized as prepolymers to synthesize glycopolymers via postpolymerization modification. Living radical polymerization with RAFT agents succeeded using not only MASI but also ASI. While the polymerization with ATRP initiator did not succeed using ASI, the procedure was successful with MASI. MASI was also applicable for SI-ATRP reactions on substrate surfaces. The introduction rate of NH2-terminated saccharide onto the prepolymer via amine coupling reaction was affected by the reaction temperature. This preparation procedure via postpolymerization modification is expected to provide a facile method for various functional polymers, such as other saccharide and beneficial ligands.