Cholinergic Control of Gamma Power in the Midbrain Spatial Attention Network
Cholinergic Control of Gamma Power in the Midbrain Spatial Attention Network
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DOI：
10.1523/jneurosci.4001-14.2015
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发表时间：
2015-01-14
影响因子：
5.3
通讯作者：
Knudsen, Eric I.
中科院分区：
文献类型：
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作者：
Bryant, Astra S.;Goddard, C. Alex;Knudsen, Eric I.
伽马功率（25-90 Hz）的调制与注意力有关，并且已经在物种和大脑区域中观察到。然而，控制这些调制的机制知之甚少。鸟类的中脑空间注意力网络在局部场电位中产生高振幅的伽马振荡，这些振荡被认为代表了注意力的最高优先位置。在这里，我们探索，在鸡的中脑切片，调节这些振荡的功率的机制，使用高分辨率技术，包括细胞内记录的钙成像靶向神经元。结果确定了一种特定的神经元亚型，表达非α 7烟碱乙酰胆碱受体，直接驱动γ产生回路中的抑制，并将网络切换到能够产生高振幅振荡的启动状态。这种机制的特殊性质使得伽马功率能够快速、持久地变化。大脑可能会在伽马能量的快速调制对信息处理至关重要的地方使用这种机制。
The modulation of gamma power (25-90 Hz) is associated with attention and has been observed across species and brain areas. However, mechanisms that control these modulations are poorly understood. The midbrain spatial attention network in birds generates high-amplitude gamma oscillations in the local field potential that are thought to represent the highest priority location for attention. Here we explore, in midbrain slices from chickens, mechanisms that regulate the power of these oscillations, using high-resolution techniques including intracellular recordings from neurons targeted by calcium imaging. The results identify a specific subtype of neuron, expressing non-alpha 7 nicotinic acetylcholine receptors, that directly drives inhibition in the gamma-generating circuit and switches the network into a primed state capable of producing high-amplitude oscillations. The special properties of this mechanism enable rapid, persistent changes in gamma power. The brain may employ this mechanism wherever rapid modulations of gamma power are critical to information processing.