Comparative performance of PET tracers in biochemical recurrence of prostate cancer: a critical analysis of literature.
Comparative performance of PET tracers in biochemical recurrence of prostate cancer: a critical analysis of literature.
复制标题
DOI：
--
复制
发表时间：
2014-09
影响因子：
2.5
通讯作者：
Chung Yao Yu;B. Desai;Lingyun Ji;S. Groshen;H. Jadvar
中科院分区：
文献类型：
--
作者：
Chung Yao Yu;B. Desai;Lingyun Ji;S. Groshen;H. Jadvar
正电子发射断层扫描（PET）与一些示踪剂针对特定的生物学特征的癌症已被探索的成像评价的患者与生化复发的前列腺癌根治性初步治疗后。然而，这些报告在研究设计、患者队列、影像学检查结果的参考标准、数据分析和数据报告方面往往是异质的。我们研究的目的是通过仅从满足预定义的患者选择标准和验证标准的研究中提取和重新分析PET检测数据来解决这些局限性。我们的研究分析了5种示踪剂（（18）F-氟脱氧葡萄糖（FDG）、（11）C-乙酸盐（ACET）、（11）C-或（18）F-胆碱（CHOL）、抗1-氨基-3-（18）F-氟环丁烷-1-羧酸（FACBC）和靶向前列腺特异性膜抗原（PSMA）的放射性标记配体）、2种治疗类型（根治性直肠切除术和放射治疗），以及检测到的疾病是局部的还是转移性的，包括病变类型（骨、淋巴结、软组织）。FDG对任何可疑疾病的检出率最低。ACET在检测局部复发和淋巴结病变方面优于CHOL，尽管差异无统计学意义。与CHOL相比，FACBC检测局部复发的可能性更大，尽管这种差异没有统计学意义。与其他四种示踪剂相比，PSMA倾向于显示更高比例的疑似疾病患者。接受放射治疗的患者在PET上显示局部复发的几率比接受根治性直肠癌切除术的患者大。我们还为未来的调查提供了建议，以促进沟通和调查结果的影响。
Positron emission tomography (PET) with a number of tracers targeted to particular biological features of cancer has been explored for the imaging evaluation of patients with biochemical recurrence of prostate cancer after curative primary treatment. However, these reports are often heterogeneous in study design, patient cohorts, standards of reference for the imaging findings, data analysis, and data reporting. The aim of our study was to address these limitations by extracting and re-analyzing the PET detection data only from studies that satisfied pre-defined sets of patient selection criteria and verification standards. Our investigation analyzed the effects of 5 tracers ((18)F-fluorodeoxyglucose (FDG), (11)C-acetate (ACET), (11)C- or (18)F-choline (CHOL), anti-1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid (FACBC), and radiolabeled ligand targeted to prostate-specific membrane antigen (PSMA)), 2 treatment types (radical prostatectomy and radiation therapy), and whether the detected disease was local or metastatic, including lesion type (bone, lymph node, soft tissue). FDG exhibited the lowest detection rate for any suspected disease. ACET tended to be advantageous over CHOL in detecting local recurrence and lymph node lesions, even though the difference was not statistically significant. FACBC had greater likelihood of detecting local recurrence, when compared to CHOL, though this difference was not statistically significant. PSMA tended to show a higher proportion of patients with suspected disease compared to the other four tracers. Patients treated with radiation therapy had greater odds of displaying local recurrence on PET than those treated with radical prostatectomy. We also provide suggestions for future investigations that facilitate communication and the impact of the findings.