The Dynamics of Language Network Interactions in Lexical Selection: An Intracranial EEG Study
The Dynamics of Language Network Interactions in Lexical Selection: An Intracranial EEG Study
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DOI：
10.1093/cercor/bhaa344
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发表时间：
2021-04-01
期刊：
影响因子：
3.7
通讯作者：
Crone, Nathan E.
中科院分区：
文献类型：
--
作者：
Wang, Yujing;Korzeniewska, Anna;Crone, Nathan E.
在句子中说话需要从上下文确定的词汇表征中进行选择。虽然后颞叶皮层（PTC）和布罗卡区分别在词汇表征的存储和选择中发挥重要作用，但这些区域之间在词汇选择的典型时间尺度上的生理相互作用还没有直接的证据。使用高伽玛功率（70-150 Hz）调制索引的皮层群体活动的颅内记录，我们研究了皮层语言网络的因果动力学，而癫痫手术患者进行了一个句子完成任务，其中潜在的词汇反应的数量是系统变化的。在完成更多的反应可能性的句子，布罗卡区不仅更活跃，而且表现出更多的本地网络的相互作用和更大的自上而下的影响PTC，激活一致，和之间的竞争，更多的词汇表征。这些研究结果提供了最直接的实验支持网络动态发挥作用，在词汇选择之间的竞争替代品在语音生产。
Speaking in sentences requires selection from contextually determined lexical representations. Although posterior temporal cortex (PTC) and Broca's areas play important roles in storage and selection, respectively, of lexical representations, there has been no direct evidence for physiological interactions between these areas on time scales typical of lexical selection. Using intracranial recordings of cortical population activity indexed by high-gamma power (70-150 Hz) modulations, we studied the causal dynamics of cortical language networks while epilepsy surgery patients performed a sentence completion task in which the number of potential lexical responses was systematically varied. Prior to completion of sentences with more response possibilities, Broca's area was not only more active, but also exhibited more local network interactions with and greater top-down influences on PTC, consistent with activation of, and competition between, more lexical representations. These findings provide the most direct experimental support yet for network dynamics playing a role in lexical selection among competing alternatives during speech production.