Diffuse intrahepatic biliary strictures in sarcoidosis resembling sclerosing cholangitis - Case report and review of the literature
Diffuse intrahepatic biliary strictures in sarcoidosis resembling sclerosing cholangitis - Case report and review of the literature
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DOI：
10.1023/a:1018874612166
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发表时间：
1997-06-01
影响因子：
3.1
通讯作者：
Bass, NM
中科院分区：
文献类型：
--
作者：
Alam, I;Levenson, SD;Bass, NM
我们报告一例结节病合并严重胆汁淤积和硬化性胆管炎的胆管造影特征，对皮质类固醇治疗反应显著。虽然结节病和原发性硬化性胆管炎之间的关联已被以前的报告，功能提示原发性硬化性胆管炎，包括炎症性肠病，肝组织学和血清中性粒细胞胞浆抗体，在这种情况下，是不存在的。胆管造影可能有助于评价胆汁淤积性结节病肝病患者，肝内胆管狭窄应包括在结节病肝脏受累的范围内。对结节病累及胆管的患者进行糖皮质激素治疗试验可能有益。
We report a case of sarcoidosis with severe cholestasis and cholangiographic features of sclerosing cholangitis that responded dramatically to corticosteroid therapy. Although an association between sarcoidosis and primary sclerosing cholangitis has been suggested by previous reports, features suggestive of primary sclerosing cholangitis, including inflammatory bowel disease, hepatic histology and serum neutrophil cytoplasmic antibodies, were absent in this case. Cholangiography may be useful in the evaluation of patients with cholestatic sarcoid liver disease, and intrahepatic biliary strictures should be included in the spectrum of hepatic involvement by sarcoidosis. A trial of corticosteroid therapy may be of benefit in patients with bile ductal involvement by sarcoidosis.