DIACYLGLYCEROL KINASE - A KEY MODULATOR OF SIGNAL TRANSDUCTION
DIACYLGLYCEROL KINASE - A KEY MODULATOR OF SIGNAL TRANSDUCTION
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DOI：
10.1016/0968-0004(90)90172-8
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发表时间：
1990-02-01
影响因子：
13.8
通讯作者：
SAKANE, F
中科院分区：
文献类型：
--
作者：
KANOH, H;YAMADA, K;SAKANE, F
动物细胞中二酰基甘油代谢概述。根据细胞的生理条件，DG可能由五种来源产生：（1）PA从头合成途径;（2）磷脂酰肌醇（磷脂酶C）;（3）PC（磷脂酶C）;（4）TG（脂肪酶）;（5）2-MG（酰基转移酶）。磷脂酶C作用于PIP 2的作用已经很好地确定，但是其他途径在产生DG中的作用仍有待确定。在细胞刺激后，DG被DGK磷酸化（6）以产生PA，PA然后用于通过CDP-二酰基甘油再合成磷脂酰肌醇（7）。DG可被脂肪酶水解为2-MG（8），2-MG是DGK的体外底物（9）。为了简单起见，省略了反应的细节和与本讨论不直接相关的那些。有关其他详细信息，请参见参考文献41。
Outline of diacylglycerol metabolism in animal cells. Depending on physiological conditions of cells, DG can potentially be generated from five sources:(1) from PA in de novo synthetic pathway;(2) from phosphatidylinositols (phospholipase C);(3) from PC (phospholipase C);(4) from TG (lipase); and (5) from 2-MG (acyltransferase). The role of phospholipase C acting on PIP 2 has been well established, but the contribution of other pathways in generating DG remains to be defined. Upon ceil stimulation DG is phosphorylated by DGK (6) to yield PA, which is then used for resynthesis of phosphatidylinositols via CDP-diacylglycerol (7). DG may be hydrolysed by a lipase to 2-MG (8), which is a substrate in vitro of DGK (9). For simplicity details of reactions and those not directly relevant to the present discussion are omitted. For other details, see Ref. 41.