Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon.
Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon.
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DOI：
10.1002/9780470994030.ch16
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发表时间：
2007
影响因子：
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通讯作者：
M. Piper;Amber-Lee S Dawson;Charlotta Lindwall;G. Barry;C. Plachez;L. Richards
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文献类型：
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作者：
M. Piper;Amber-Lee S Dawson;Charlotta Lindwall;G. Barry;C. Plachez;L. Richards
EMX和核因子1(NFI)基因编码转录因子，调节许多胚胎发育过程。哺乳动物的两个EMX基因Emx1和Emx2在胚胎皮质中表达，调节皮质沿着肩尾轴分布到不同的感觉和运动区。到目前为止，很少有发育过程专门归因于Emx1，大多数分析表明Emx1和Emx2之间存在功能冗余，其中Emx2对发育最重要。在这里，我们提供了Emx1和Emx2在愈伤组织形成过程中调节不同发育过程的证据，并综述了这两个基因如何在细胞迁移和皮质轴突投射的形成中发挥作用。NFI基因家族由四个成员组成：NfiA、NFIB、NFIC和Nfix。表达分析表明，NfiA、NFIB和Nfix在发育中的端脑中均有表达。它们在构图、神经胶质发育、皮质细胞迁移和轴突引导方面发挥作用。我们回顾了这些基因在皮质细胞迁移、胶质发育和皮质轴突投射形成中的作用，并检查了EMX和NFI基因家族之间的重叠突变表型。
The Emx and Nuclear Factor One (Nfi) genes encode transcription factors that regulate numerous embryonic developmental processes. The two mammalian Emx genes, Emx1 and Emx2, are expressed in the embryonic cortex and regulate the specification of the cortex into different sensory and motor areas along the rostrocaudal axis. To date, few developmental processes have been attributed specifically to Emx1, with most analyses demonstrating a redundancy of function between Emx1 and Emx2, with Emx2 being most essential for development. Here we provide evidence that Emx1 and Emx2 regulate different developmental processes during corpus callosum formation and review how both genes function in cellular migration and the formation of cortical axon projections. The Nfi gene family is made up of four members, Nfia, Nfib, Nfic and Nfix. Expression analyses show that Nfia, Nfib and Nfix are expressed in the developing telencephalon. They play roles in patterning, glial development, cortical cell migration and axon guidance. We review the role of these genes in cortical cell migration, glial development and the formation of cortical axon projections, and examine the overlapping mutant phenotypes between the Emx and Nfi gene families.