Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder
Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder
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DOI：
10.1542/peds.104.2.e20
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发表时间：
1999-08-01
期刊：
影响因子：
8
通讯作者：
Faraone, SV
中科院分区：
文献类型：
--
作者：
Biederman, J;Wilens, T;Faraone, SV
Objective.在一项对注意力缺陷多动障碍（ADHD）男孩的纵向研究中，评估与既往精神药物暴露相关的物质使用障碍（SUD）风险。对56名服药的ADHD患者、19名未服药的ADHD患者和137名非ADHD对照者在整个青春期的SUD累积发生率进行比较。与非ADHD对照受试者相比，未用药的ADHD受试者在随访时发生任何SUD的风险显著增加（校正OR：6.3 [1.8-21.6]）。基线时接受药物治疗的ADHD受试者在随访时发生SUD的风险显著低于未接受药物治疗的ADHD受试者（校正OR：0.15 [0.04-0.6]）。对于每个SUD亚型研究，暴露于药物治疗的效果的方向是相似的，看到任何SUD类别。与成人中未经治疗的ADHD的发现一致，未经治疗的ADHD是青春期SUD的重要危险因素。相比之下，药物治疗与ADHD青少年SUD风险降低85%相关。
Objective. To assess the risk for substance use disorders (SUD) associated with previous exposure to psychotropic medication in a longitudinal study of boys with attention-deficit/hyperactivity disorder (ADHD).Methods. The cumulative incidence of SUD throughout adolescence was compared in 56 medicated subjects with ADHD, 19 nonmedicated subjects with ADHD, and 137 non-ADHD control subjects.Results. Unmedicated subjects with ADHD were at a significantly increased risk for any SUD at follow-up compared with non-ADHD control subjects (adjusted OR: 6.3 [1.8-21.6]). Subjects with ADHD medicated at baseline were ata significantly reduced risk for a SUD at follow-up relative to untreated subjects with ADHD (adjusted OR: 0.15 [0.04-0.6]). For each SUD subtype studied, the direction of the effect of exposure to pharmacotherapy was similar to that seen for the any SUD category.Conclusions. Consistent with findings in untreated ADHD in adults, untreated ADHD was a significant risk factor for SUD in adolescence. In contrast, pharmacotherapy was associated with an 85% reduction in risk for SUD in ADHD youth.