Substrate topography shapes cell function
Substrate topography shapes cell function
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DOI：
10.1039/b910132m
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发表时间：
2009-01-01
期刊：
影响因子：
3.4
通讯作者：
Leong, Kam W.
中科院分区：
文献类型：
--
作者：
Kulangara, Karina;Leong, Kam W.
使用基质或植入物形貌影响细胞从增殖到分化的行为对于再生医学应用来说是一种有吸引力的策略。亚微米范围内的基质形貌特别令人感兴趣，因为其尺寸范围与细胞外基质结构相当。新兴文献提出了许多关于纳米形貌如何增强细胞粘附、改变细胞形态、影响增殖、启动细胞内信号传导、提供接触引导和介导干细胞分化的有趣发现。鉴于这些研究和纳米制造技术进步的实用性，将地形考虑纳入细胞培养仿生微环境的设计将变得越来越重要。这一亮点强调了关于地形效应在操纵细胞-基质相互作用和推进组织工程方面的前景和未知信息。
Influencing cell behavior from proliferation to differentiation using substrate or implant topography is an attractive strategy for regenerative medicine applications. Substrate topography at the submicron range is of particular interest because the size range is comparable to extracellular matrix structures. Emerging literature presents many interesting findings on how nanotopography enhances cell adhesion, alters cell morphology, affects proliferation, initiates intracellular signaling, provides contact guidance and mediates stem cell differentiation. Incorporating topographical consideration into the design of a biomimetic microenvironment for cell culture will become increasingly important in light of these studies and practical with advances in nanofabrication technologies. This Highlight underscores the promise of and the unknown information about topographical effects in manipulating cell-substrate interaction and advancing tissue engineering.