Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration.
Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration.
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DOI：
10.1016/j.cell.2011.05.004
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发表时间：
2011-06-10
期刊：
影响因子：
64.5
通讯作者：
Ito M
中科院分区：
文献类型：
--
作者：
Rabbani P;Takeo M;Chou W;Myung P;Bosenberg M;Chin L;Taketo MM;Ito M
黑素细胞干细胞（McSCs）与毛囊隆突部和次级毛芽（sHG）中的上皮干细胞（EpSCs）密切相互作用。它们共同经历激活和分化以再生有色素的毛发。然而，这种干细胞协同行为背后的机制尚未阐明。在此，我们确定Wnt信号通路是连接这两种干细胞行为的关键途径。在sHG内毛囊再生开始时，EpSCs和McSCs协同激活Wnt信号通路。利用特异性靶向EpSCs或McSCs的基因小鼠模型，我们表明McSCs中的Wnt激活驱动它们分化为产生色素的黑素细胞，而EpSC的Wnt信号不仅决定毛囊形成，还在毛发再生过程中调节McSC的增殖。我们的数据明确了Wnt信号在McSCs调节中的作用，也阐明了一种通过不同类型干细胞群体之间协作来实现复杂器官再生的机制。
Melanocyte stem cells (McSCs) intimately interact with epithelial stem cells (EpSCs) in the hair follicle bulge and secondary hair germ (sHG). Together, they undergo activation and differentiation to regenerate pigmented hair. However, the mechanisms behind this coordinated stem cell behavior have not been elucidated. Here, we identified Wnt signaling as a key pathway that couples the behavior of the two stem cells. EpSCs and McSCs coordinately activate Wnt signaling at the onset of hair follicle regeneration within the sHG. Using genetic mouse models that specifically target either EpSCs or McSCs, we show that Wnt activation in McSCs drives their differentiation into pigment-producing melanocytes, while EpSC Wnt signaling not only dictates hair follicle formation but also regulates McSC proliferation during hair regeneration. Our data define a role for Wnt signaling in the regulation of McSCs and also illustrate a mechanism for regeneration of complex organs through collaboration between heterotypic stem cell populations.
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影响因子：
8
作者：
Kim, TH;Xiong, H;Ren, B
通讯作者：
Ren, B
影响因子：
10.5
作者：
Delmas, Veronique;Beermann, Friedrich;Larue, Lionel
通讯作者：
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影响因子：
1.5
作者：
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影响因子：
64.8
作者：
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通讯作者：
Raible, DW
DOI：
10.1073/pnas.97.18.10050
发表时间：
2000-08-29
影响因子：
11.1
作者：
Dunn, KJ;Williams, BO;Pavan, WJ
通讯作者：
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